Inhibitory Effects of Myrtucommuacetalone 1 (MCA-1) from Myrtus communis on Inflammatory Response in Mouse Macrophages

(1) Introduction: Reactive oxygen species (ROS) and nitric oxide (NO) are key signaling molecules that play important roles in the progression of inflammatory disorders. The objective of this study was to explore the use of myrtucommuacetalone-1 (MCA-1), as a novel compound of natural origin and a p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2019-12, Vol.25 (1), p.13
Hauptverfasser:	Soomro, Samreen, Mesaik, M Ahmed, Shaheen, Farzana, Khan, Noureen, Halim, Sobia Ahsan, Ul-Haq, Zaheer, Ali Siddiqui, Rafat, Choudhary, Muhammad Iqbal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-inflammatory agents Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Bioavailability Cardiovascular disease Cell Line Chemical compounds Cytokines Cytotoxicity Drug dosages Enzymes Epithelial cells Epithelium Fibroblasts Gene expression Hepatocytes Humans Hydrogen peroxide Inflammation Inflammatory diseases Inflammatory response Introduced species Investigations Kinases Lipopolysaccharides - immunology Lung cancer Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Models, Molecular Molecular Structure Myrtus - chemistry NF-kappa B - chemistry NF-kappa B - metabolism NF-κB protein Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - chemistry Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase p38 Mitogen-Activated Protein Kinases - chemistry p38 Mitogen-Activated Protein Kinases - metabolism Permeability Pharmacology Phloroglucinol Phosphorylation Reactive oxygen species Reactive Oxygen Species - metabolism Respiratory Burst - drug effects Respiratory Burst - immunology Sepsis Structure-Activity Relationship Superoxide Transcription factors Translocation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	(1) Introduction: Reactive oxygen species (ROS) and nitric oxide (NO) are key signaling molecules that play important roles in the progression of inflammatory disorders. The objective of this study was to explore the use of myrtucommuacetalone-1 (MCA-1), as a novel compound of natural origin and a potential anti-inflammatory agent. (2) Methodology: The anti-inflammatory potential of MCA-1, which was isolated from Linn, was determined by assaying superoxide, hydrogen peroxide, and nitric oxide production in macrophages. Furthermore, the effects of the compound were analyzed via phosphorylation and translocation of the transcription factor NF kappa B, which is a key regulator of iNOS activation. The effect of MCA-1 on the inducible nitric oxide synthase (iNOS) enzyme was also examined using in silico docking studies. The anticancer potential for MCA-1 was evaluated with an MTT cytotoxic assay. (3) Results: In stimulated macrophages, MCA-1 inhibited superoxide production by 48%, hydrogen peroxide by 53%, and nitric oxide (NO) with an IC of
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25010013