Near Infrared-Activated Dye-Linked ZnO Nanoparticles Release Reactive Oxygen Species for Potential Use in Photodynamic Therapy

Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time...

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Veröffentlicht in:	Materials 2019-12, Vol.13 (1), p.17
Hauptverfasser:	Nagi, Jaspreet Singh, Skorenko, Kenneth, Bernier, William, Jones, Wayne E, Doiron, Amber L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocompatibility Biomedical materials Cytotoxicity Dyes Endothelial cells Ethylene glycol Fourier transforms Hemodialysis Infrared radiation Irradiation Light Low concentrations Nanoparticles Photodynamic therapy Scanning electron microscopy Toxicity Zeta potential Zinc oxide Zinc oxides
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Beschreibung
Zusammenfassung:	Novel dye-linked zinc oxide nanoparticles (NPs) hold potential as photosensitizers for biomedical applications due to their excellent thermal- and photo-stability. The particles produced reactive oxygen species (ROS) upon irradiation with 850 nm near infrared (NIR) light in a concentration- and time-dependent manner. Upon irradiation, ROS detected in vitro in human umbilical vein endothelial cells (HUVEC) and human carcinoma MCF7 cells positively correlated with particle concentration and interestingly, ROS detected in MCF7 was higher than in HUVEC. Preferential cytotoxicity was also exhibited by the NPs as cell killing was higher in MCF7 than in HUVEC. In the absence of irradiation, dye-linked ZnO particles minimally affected the viability of cell (HUVEC) at low concentrations (
ISSN:	1996-1944 1996-1944
DOI:	10.3390/ma13010017