Viral and Host Factors are Related to the Progression of HIV Diseases in Mimika, Papua

Papua has a high cumulative number of HIV, which has expanded epidemic status with the most risk factors are heterosexuals. This study aims to determine factors associated with HIV disease progression include host and viral factors. Eighty-four subjects recruited in Rumah Sakit Mitra Masyarakat (RSMM) VCT's laboratory, interviewed with questionnaires and also did laboratory examinations. HIV-1 subtypes were identified using RT-PCR, nested PCR and sequencing. Then, CD4+ data is checked using PIMA Analyzer. Demographic and clinical data obtained from the patient's medical record. After collected, data were analysed using Fisher's exact test. The results showed two factors that influence the progression of HIV disease were HIV subtypes (p = 0.002) and Body Mass Index (p = 0.033). The HIV-1 subtype also correlated with CD4+ levels with a value of p = 0.04. HIV-1 subtype correlates with HIV progression, so it is necessary to develop HIV/AIDS management strategies and clinical counselling.