Chemoenzymatic Halocyclization of γ,δ‐Unsaturated Carboxylic Acids and Alcohols

A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using the robust V‐dependent chloroperoxidase from Curvularia inaequalis (CiVCPO) as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent performance of the biocatalyst. You had me at “halo”: A chemoenzymatic method for the halocyclization of unsaturated alcohols and acids by using a robust V‐dependent chloroperoxidase as catalyst has been developed for the in situ generation of hypohalites. A broad range of halolactones and cyclic haloethers are formed with excellent biocatalyst performance.