Long‐term renal follow up of preterm neonates born before 35 weeks of gestation

Background The hypothesis of the Developmental Origins of Health and Disease states that environmental factors during fetal and infantile life are risk factors for some chronic diseases in adulthood. Few studies, however, have confirmed this hypothesis early in childhood. Therefore, we assessed how premature birth and low‐birthweight (LBW) affect the renal function of Japanese children. Methods This retrospective study surveyed 168 patients who were born before 35 weeks of gestation and were cared for at the present neonatal intensive care unit. Follow‐up duration was >2 years. Serum creatinine (sCr) and estimated glomerular filtration rate (eGFR) recorded in medical records were reviewed. Results The eGFR at 2 years of age was significantly correlated with birthweight and gestational age (P