Utility of genetic variants to predict prognosis in coronary artery disease patients receiving statin treatment

Utility of genetic variants to predict prognosis in coronary artery disease patients receiving statin treatment

Statins are widely used drugs for lowering low-density lipoprotein cholesterol (LDL-C) and can prevent cardiovascular events. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) and their cumulative effects on the prognosis of coronary artery disease (CAD) patients t...

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Veröffentlicht in:International journal of clinical and experimental pathology 2017-01, Vol.10 (8), p.8795-8803
Hauptverfasser: Zhu, Li, Ji, Xiaoli, Jiang, Lin, Zhu, Yabin, Xu, Yumin, Jiang, Qinxiao, Bao, Jingjing, Ye, Jun, Sheng, Haihui, Yu, Hong
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Sprache:eng
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Zusammenfassung:Statins are widely used drugs for lowering low-density lipoprotein cholesterol (LDL-C) and can prevent cardiovascular events. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) and their cumulative effects on the prognosis of coronary artery disease (CAD) patients treated with statins. Sixteen SNPs were genotyped in 785 CAD patients receiving statin therapy, and their associations with clinical features and prognosis of patients were investigated. Four SNPs (rs2296651, rs11206510, rs8192870, and rs1801133) were significantly associated with complications of CAD (
ISSN:1936-2625