Nitrogen-bound diazeniumdiolated amidines

Nitrogen-bound diazeniumdiolated amidines

In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-08, Vol.46 (31), p.5799-5801
Hauptverfasser: Biswas, Debanjan, Deschamps, Jeffrey R, Keefer, Larry K, Hrabie, Joseph A
Format: Artikel
Sprache:eng
Schlagworte:
Amidines - chemical synthesis
Amidines - chemistry
Azo Compounds - chemistry
Molecular Conformation
Nitric Oxide - chemistry
Nitrogen - chemistry
Prodrugs - chemical synthesis
Prodrugs - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c0cc00849d