Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis
Accumulation of bile acids (BAs) may mediate development of necrotizing enterocolitis (NEC). Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and
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| Veröffentlicht in: | Scientific reports 2020-01, Vol.10 (1), p.249-249, Article 249 |
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| creator | Knapp, Shannon Kehring, Allysa Stepp, Jennifer Calton, Christine M. Gephart, Sheila M. Bandlamuri, Sruti Boyle, Kate E. Dietz, Grey I. Johnson, Haeley Romo, Ryan E. Spencer, Mackenzie Bedrick, Alan D. Halpern, Melissa D. |
| description | Accumulation of bile acids (BAs) may mediate development of necrotizing enterocolitis (NEC). Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and |
| doi_str_mv | 10.1038/s41598-019-57178-0 |
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Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and <30 days old prior to initiation of enteral feeding. Nine infants that developed Bell’s Stage ≥ II NEC were matched with control infants based on BW, EGA, day of life (DOL) enteral feeding was initiated and DOL of the first sample. From each subject, five samples matched by DOL collected were analyzed for BA levels and composition. Fifteen individual BA species were measured via LC-MS/MS and total BA levels were measured using the Diazyme Total Bile Acid Assay kit. No statistically significant differences in composition were observed between control and NEC at the level of individual species (p = 0.1133) or grouped BAs (p = 0.0742). However, there was a statistically significant difference (p = 0.000012) in the mean coefficient of variation (CV) between the two groups with infants developing NEC having more than four-fold higher mean CV than controls. Importantly, these variations occurred prior to NEC diagnosis. These data suggest fluctuations in total fecal BA levels could provide the basis for the first predictive clinical test for NEC.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-57178-0</identifier><identifier>PMID: 31937876</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 692/4020/1503/1581/3189 ; 692/53/2423 ; Acids ; Bile ; Bile acids ; Bile Acids and Salts - chemistry ; Bile Acids and Salts - metabolism ; Birth weight ; Coefficient of variation ; Diagnosis ; Enteral feeding ; Enteral nutrition ; Enterocolitis ; Enterocolitis, Necrotizing - diagnosis ; Enterocolitis, Necrotizing - metabolism ; Feces ; Feces - chemistry ; Female ; Gastrointestinal diseases ; Gestational age ; Humanities and Social Sciences ; Humans ; Infant ; Infants ; Male ; multidisciplinary ; Necrosis ; Necrotizing enterocolitis ; Science ; Science (multidisciplinary) ; Statistical analysis ; Variation</subject><ispartof>Scientific reports, 2020-01, Vol.10 (1), p.249-249, Article 249</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-b37f0bd7fdf430b32faa629d51138d93310931c4f53ffa82bad0e9bc0a84aa9c3</citedby><cites>FETCH-LOGICAL-c474t-b37f0bd7fdf430b32faa629d51138d93310931c4f53ffa82bad0e9bc0a84aa9c3</cites><orcidid>0000-0002-0120-7404 ; 0000-0002-5189-5006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959237/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959237/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31937876$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Knapp, Shannon</creatorcontrib><creatorcontrib>Kehring, Allysa</creatorcontrib><creatorcontrib>Stepp, Jennifer</creatorcontrib><creatorcontrib>Calton, Christine M.</creatorcontrib><creatorcontrib>Gephart, Sheila M.</creatorcontrib><creatorcontrib>Bandlamuri, Sruti</creatorcontrib><creatorcontrib>Boyle, Kate E.</creatorcontrib><creatorcontrib>Dietz, Grey I.</creatorcontrib><creatorcontrib>Johnson, Haeley</creatorcontrib><creatorcontrib>Romo, Ryan E.</creatorcontrib><creatorcontrib>Spencer, Mackenzie</creatorcontrib><creatorcontrib>Bedrick, Alan D.</creatorcontrib><creatorcontrib>Halpern, Melissa D.</creatorcontrib><title>Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Accumulation of bile acids (BAs) may mediate development of necrotizing enterocolitis (NEC). Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and <30 days old prior to initiation of enteral feeding. Nine infants that developed Bell’s Stage ≥ II NEC were matched with control infants based on BW, EGA, day of life (DOL) enteral feeding was initiated and DOL of the first sample. From each subject, five samples matched by DOL collected were analyzed for BA levels and composition. Fifteen individual BA species were measured via LC-MS/MS and total BA levels were measured using the Diazyme Total Bile Acid Assay kit. No statistically significant differences in composition were observed between control and NEC at the level of individual species (p = 0.1133) or grouped BAs (p = 0.0742). However, there was a statistically significant difference (p = 0.000012) in the mean coefficient of variation (CV) between the two groups with infants developing NEC having more than four-fold higher mean CV than controls. Importantly, these variations occurred prior to NEC diagnosis. These data suggest fluctuations in total fecal BA levels could provide the basis for the first predictive clinical test for NEC.</description><subject>101/58</subject><subject>692/4020/1503/1581/3189</subject><subject>692/53/2423</subject><subject>Acids</subject><subject>Bile</subject><subject>Bile acids</subject><subject>Bile Acids and Salts - chemistry</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Birth weight</subject><subject>Coefficient of variation</subject><subject>Diagnosis</subject><subject>Enteral feeding</subject><subject>Enteral nutrition</subject><subject>Enterocolitis</subject><subject>Enterocolitis, Necrotizing - diagnosis</subject><subject>Enterocolitis, Necrotizing - metabolism</subject><subject>Feces</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Gastrointestinal diseases</subject><subject>Gestational age</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infant</subject><subject>Infants</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Necrosis</subject><subject>Necrotizing enterocolitis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Statistical analysis</subject><subject>Variation</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1vVCEUhonR2Kb2D7gwJG7cXOVzuGxM6jhVk6a6qG4JFw4j9Q5UYJrYX1_q1FpdlATOSc5zXji8CD2n5DUlfHxTBZV6HAjVg1RU9ewR2mdEyIFxxh7fy_fQYa3npC_JtKD6KdrjVHM1qsU--rGa4dI28HiZIYToIqSGc8DfbIm2xZxwTPgsNzvjY3D9fBdnwEcu-oq_FHDgoeL30a5TrrHedJ6CK7nFq5jWeJUalOzyHFusz9CTYOcKh7fxAH09Xp0tPw4nnz98Wh6dDE4o0YaJq0Amr4IPgpOJs2DtgmkvKeWj15xTojl1Ikgegh3ZZD0BPTliR2GtdvwAvd3pXmynDXjXJyp2Nhclbmz5ZbKN5t9Kit_NOl-ahZaacdUFXt0KlPxzC7WZTawO5tkmyNtqGOej1pRK2dGX_6HneVtSH69Tgve9UKJTbEf1n6m1QLh7DCXmxk6zs9N0O81vOw3pTS_uj3HX8se8DvAdUHspraH8vfsB2WsBBayF</recordid><startdate>20200114</startdate><enddate>20200114</enddate><creator>Knapp, Shannon</creator><creator>Kehring, Allysa</creator><creator>Stepp, Jennifer</creator><creator>Calton, Christine M.</creator><creator>Gephart, Sheila M.</creator><creator>Bandlamuri, Sruti</creator><creator>Boyle, Kate E.</creator><creator>Dietz, Grey I.</creator><creator>Johnson, Haeley</creator><creator>Romo, Ryan E.</creator><creator>Spencer, Mackenzie</creator><creator>Bedrick, Alan D.</creator><creator>Halpern, Melissa D.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0120-7404</orcidid><orcidid>https://orcid.org/0000-0002-5189-5006</orcidid></search><sort><creationdate>20200114</creationdate><title>Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis</title><author>Knapp, Shannon ; Kehring, Allysa ; Stepp, Jennifer ; Calton, Christine M. ; Gephart, Sheila M. ; Bandlamuri, Sruti ; Boyle, Kate E. ; Dietz, Grey I. ; Johnson, Haeley ; Romo, Ryan E. ; Spencer, Mackenzie ; Bedrick, Alan D. ; Halpern, Melissa D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-b37f0bd7fdf430b32faa629d51138d93310931c4f53ffa82bad0e9bc0a84aa9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>101/58</topic><topic>692/4020/1503/1581/3189</topic><topic>692/53/2423</topic><topic>Acids</topic><topic>Bile</topic><topic>Bile acids</topic><topic>Bile Acids and Salts - chemistry</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Birth weight</topic><topic>Coefficient of variation</topic><topic>Diagnosis</topic><topic>Enteral feeding</topic><topic>Enteral nutrition</topic><topic>Enterocolitis</topic><topic>Enterocolitis, Necrotizing - diagnosis</topic><topic>Enterocolitis, Necrotizing - metabolism</topic><topic>Feces</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Gastrointestinal diseases</topic><topic>Gestational age</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infant</topic><topic>Infants</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Necrosis</topic><topic>Necrotizing enterocolitis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Statistical analysis</topic><topic>Variation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Knapp, Shannon</creatorcontrib><creatorcontrib>Kehring, Allysa</creatorcontrib><creatorcontrib>Stepp, Jennifer</creatorcontrib><creatorcontrib>Calton, Christine M.</creatorcontrib><creatorcontrib>Gephart, Sheila M.</creatorcontrib><creatorcontrib>Bandlamuri, Sruti</creatorcontrib><creatorcontrib>Boyle, Kate E.</creatorcontrib><creatorcontrib>Dietz, Grey I.</creatorcontrib><creatorcontrib>Johnson, Haeley</creatorcontrib><creatorcontrib>Romo, Ryan E.</creatorcontrib><creatorcontrib>Spencer, Mackenzie</creatorcontrib><creatorcontrib>Bedrick, Alan D.</creatorcontrib><creatorcontrib>Halpern, Melissa D.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Knapp, Shannon</au><au>Kehring, Allysa</au><au>Stepp, Jennifer</au><au>Calton, Christine M.</au><au>Gephart, Sheila M.</au><au>Bandlamuri, Sruti</au><au>Boyle, Kate E.</au><au>Dietz, Grey I.</au><au>Johnson, Haeley</au><au>Romo, Ryan E.</au><au>Spencer, Mackenzie</au><au>Bedrick, Alan D.</au><au>Halpern, Melissa D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-01-14</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>249</spage><epage>249</epage><pages>249-249</pages><artnum>249</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Accumulation of bile acids (BAs) may mediate development of necrotizing enterocolitis (NEC). Serial fecal samples were collected from premature infants with birth weight (BW) ≤ 1800 g, estimated gestational age (EGA) ≤ 32 weeks, and <30 days old prior to initiation of enteral feeding. Nine infants that developed Bell’s Stage ≥ II NEC were matched with control infants based on BW, EGA, day of life (DOL) enteral feeding was initiated and DOL of the first sample. From each subject, five samples matched by DOL collected were analyzed for BA levels and composition. Fifteen individual BA species were measured via LC-MS/MS and total BA levels were measured using the Diazyme Total Bile Acid Assay kit. No statistically significant differences in composition were observed between control and NEC at the level of individual species (p = 0.1133) or grouped BAs (p = 0.0742). However, there was a statistically significant difference (p = 0.000012) in the mean coefficient of variation (CV) between the two groups with infants developing NEC having more than four-fold higher mean CV than controls. Importantly, these variations occurred prior to NEC diagnosis. These data suggest fluctuations in total fecal BA levels could provide the basis for the first predictive clinical test for NEC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31937876</pmid><doi>10.1038/s41598-019-57178-0</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-0120-7404</orcidid><orcidid>https://orcid.org/0000-0002-5189-5006</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 101/58 692/4020/1503/1581/3189 692/53/2423 Acids Bile Bile acids Bile Acids and Salts - chemistry Bile Acids and Salts - metabolism Birth weight Coefficient of variation Diagnosis Enteral feeding Enteral nutrition Enterocolitis Enterocolitis, Necrotizing - diagnosis Enterocolitis, Necrotizing - metabolism Feces Feces - chemistry Female Gastrointestinal diseases Gestational age Humanities and Social Sciences Humans Infant Infants Male multidisciplinary Necrosis Necrotizing enterocolitis Science Science (multidisciplinary) Statistical analysis Variation |
| title | Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis |
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