Population pharmacokinetics of sildenafil in extremely premature infants

Aims To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. Methods We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of clinical pharmacology 2019-12, Vol.85 (12), p.2824-2837
Hauptverfasser:	Gonzalez, Daniel, Laughon, Matthew M., Smith, P. Brian, Ge, Shufan, Ambalavanan, Namasivayam, Atz, Andrew, Sokol, Gregory M., Hornik, Chi D., Stewart, Dan, Mundakel, Gratias, Poindexter, Brenda B., Gaedigk, Roger, Mills, Mary, Cohen‐Wolkowiez, Michael, Martz, Karen, Hornik, Christoph P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Cohort Studies Cytochrome P-450 CYP3A - blood Cytochrome P-450 CYP3A - genetics Fluconazole - administration & dosage Fluconazole - pharmacokinetics Gestational Age Humans Hypertension, Pulmonary - blood Hypertension, Pulmonary - drug therapy Infant Infant, Newborn Infant, Premature - blood Infant, Premature, Diseases - blood Infant, Premature, Diseases - drug therapy Injections, Intravenous Models, Biological Original pharmacokinetics Phosphodiesterase 5 Inhibitors - administration & dosage Phosphodiesterase 5 Inhibitors - blood Phosphodiesterase 5 Inhibitors - pharmacokinetics Phosphodiesterase 5 Inhibitors - therapeutic use premature infants sildenafil Sildenafil Citrate - administration & dosage Sildenafil Citrate - blood Sildenafil Citrate - pharmacokinetics Sildenafil Citrate - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Aims To characterize the population pharmacokinetics (PK) of sildenafil and its active metabolite, N‐desmethyl sildenafil (DMS), in premature infants. Methods We performed a multicentre, open‐label trial to characterize the PK of sildenafil in infants ≤28 weeks gestation and
ISSN:	0306-5251 1365-2125 1365-2125
DOI:	10.1111/bcp.14111