Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy

Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mucositis induced by chemotherapy

CIRM-BIA 129 ( wild type, WT) is a probiotic bacterium, which exerts immunomodulatory effects. This strain possesses extractable surface proteins, including SlpB, which are involved in anti-inflammatory effect and in adhesion to epithelial cells. We decided to investigate the impact of gene mutation...

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Veröffentlicht in:Oncotarget 2019-12, Vol.10 (68), p.7198-7219
Hauptverfasser: do Carmo, Fillipe Luiz Rosa, Rabah, Houem, Cordeiro, Barbara Fernandes, da Silva, Sara Heloisa, Pessoa, Rafaela Miranda, Fernandes, Simone Odília Antunes, Cardoso, Valbert Nascimento, Gagnaire, Valérie, Deplanche, Martine, Savassi, Bruna, Figueiroa, Alessandra, Oliveira, Emiliano Rosa, Fonseca, Caio César, Queiroz, Maria Izabel Alves, Rodrigues, Núbia Morais, Sandes, Sávio Henrique de Cicco, Nunes, Álvaro Cantini, Lemos, Luisa, Alves, Juliana de Lima, Faria, Ana Maria Caetano, Ferreira, Ênio, Le Loir, Yves, Jan, Gwénaël, Azevedo, Vasco
Format: Artikel
Sprache:eng
Schlagworte:
Food and Nutrition
Life Sciences
Microbiology and Parasitology
Research Paper
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Zusammenfassung:CIRM-BIA 129 ( wild type, WT) is a probiotic bacterium, which exerts immunomodulatory effects. This strain possesses extractable surface proteins, including SlpB, which are involved in anti-inflammatory effect and in adhesion to epithelial cells. We decided to investigate the impact of gene mutation on immunomodulation and . In an assay, WT reduced expression of IL-8 (p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.27319