TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway

TMEFF2 inhibits pancreatic cancer cells proliferation, migration, and invasion by suppressing phosphorylation of the MAPK signaling pathway

This paper studied the effect of TMEFF2 expression on pancreatic cancer and its mechanism. A total of 72 pancreatic cancer patients were enrolled. AsPC1 and Panc1 cells were transfected. SB203580 was used to treat AsPC1 cells. CCK8 assay, colony formation analysis, Transwell experiment and Tunel tes...

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Veröffentlicht in:OncoTargets and therapy 2019-12, Vol.12, p.11371-11382
Hauptverfasser: Han, Hongchao, Zhan, Zhilin, Xu, Jie, Song, Zhenshun
Format: Artikel
Sprache:eng
Schlagworte:
Cancer cells
Cholecystokinin
Comparative analysis
Gene expression
Genes
Genetic research
Immunohistochemistry
Original Research
Proteins
Tumors
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Zusammenfassung:This paper studied the effect of TMEFF2 expression on pancreatic cancer and its mechanism. A total of 72 pancreatic cancer patients were enrolled. AsPC1 and Panc1 cells were transfected. SB203580 was used to treat AsPC1 cells. CCK8 assay, colony formation analysis, Transwell experiment and Tunel test were performed. In vivo studies in nude mice were conducted. Immunohistochemistry, qRT-PCR and Western blot were used to detect genes expression. TMEFF2 was downregulated in pancreatic cancer tissues and cells (
ISSN:1178-6930
1178-6930
DOI:10.2147/OTT.S210619