Chronotropic Incompetence and Abnormal Autonomic Modulation in Ambulatory Chagas Disease Patients

Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular...

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Veröffentlicht in:Annals of noninvasive electrocardiology 2006-01, Vol.11 (1), p.3-11
Hauptverfasser: Rocha, Ana Luiza Lunardi, Lombardi, Federico, Da Costa Rocha, Manoel Otávio, Barros, Márcio Vinícius Lins, Val Barros, Vladimir da Costa, Reis, Adelina Martha, Ribeiro, Antonio Luiz Pinho
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Sprache:eng
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Zusammenfassung:Background: Chagas disease (ChD) patients might present chronotropic incompetence during exercise, although its physiopathology remains uncertain. We evaluated the heart rate (HR) response to exercise testing in ChD patients in order to determine the role of autonomic modulation and left ventricular dysfunction in the physiopathology of chronotropic incompetence. Methods: ChD ambulatory patients (n = 170) and healthy controls (n = 24) underwent a standardized protocol including Doppler echocardiography, Holter monitoring, HR variability analysis, brain natriuretic peptide (BNP) measurement, and maximal exercise testing. The chronotropic response was calculated as the percentage of predicted HR achieved and the HR increment (ΔHR) during exercise. ChD patients were divided according to the absence or presence of cardiopathy and chronotropic incompetence (
ISSN:1082-720X
1542-474X
DOI:10.1111/j.1542-474X.2006.00054.x