Myeloid/Lymphoid Neoplasm with PDGFRB Rearrangement with t (5;10) (q33;q22) Harboring a Novel Breakpoint of the CCDC6-PDGFRB Fusion Gene

Myeloid/lymphoid neoplasms with PDGFRB rearrangement are a distinct type of myeloid neoplasms that occur in association with rearrangement of PDGFRB at 5q32. The hematological features most often show prominent eosinophilia. We herein report a patient with myeloid/lymphoid neoplasms with PDGFRB rear...

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Veröffentlicht in:Internal Medicine 2019/12/01, Vol.58(23), pp.3449-3453
Hauptverfasser: Yamazaki, Miki, Nakaseko, Chiaki, Takeuchi, Masahiro, Ozawa, Shinichi, Ishizuka, Yasuhiro, Hatanaka, Yasuhito, Oshima-Hasegawa, Nagisa, Muto, Tomoya, Tsukamoto, Shokichi, Mitsukawa, Shio, Ohwada, Chikako, Takeda, Yusuke, Mimura, Naoya, Iseki, Tohru, Fukazawa, Motoharu, Sakaida, Emiko
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Sprache:eng
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Zusammenfassung:Myeloid/lymphoid neoplasms with PDGFRB rearrangement are a distinct type of myeloid neoplasms that occur in association with rearrangement of PDGFRB at 5q32. The hematological features most often show prominent eosinophilia. We herein report a patient with myeloid/lymphoid neoplasms with PDGFRB rearrangement with t (5;10) (q33;q22) who showed atypical chronic myeloid leukemia-like clinical features without eosinophilia and achieved an optimal response to imatinib. A sequence analysis showed a CCDC6-PDGFRB fusion gene with a new break point in the PDGFRB gene. This is the sixth case of myeloid/lymphoid neoplasm with PDGFRB rearrangement harboring a CCDC6-PDGFRB fusion gene, and it has a new breakpoint in the PDGFRB fusion gene.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.3220-19