Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells

Immunohistological analyses of pancreata from patients with type 1 diabetes suggest distinct autoimmune islet β-cell pathology between those diagnosed at

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Bibliographische Detailangaben
Veröffentlicht in:	Diabetes care 2020-01, Vol.43 (1), p.169-177
Hauptverfasser:	Inshaw, Jamie R J, Cutler, Antony J, Crouch, Daniel J M, Wicker, Linda S, Todd, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age of Onset Alleles Autoantibodies - genetics Autoantibodies - immunology Beta cells Case-Control Studies Child Child, Preschool Children Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - diagnosis Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Etiology Female Genes Genetic diversity Genetic Predisposition to Disease Genetic variance Genotype Genotypes Haplotypes Histocompatibility antigen HLA Humans Immune system Immune System - metabolism Infant Infant, Newborn Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Interleukin 1 Interleukin 10 Interleukin 2 receptors Islets of Langerhans - immunology Islets of Langerhans - metabolism Loci Lymphocytes Lymphocytes T Male Medical diagnosis Middle Aged Pancreas Pathophysiology/Complications Polymorphism, Genetic Regression analysis Regression models Research design Young Adult
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Beschreibung
Zusammenfassung:	Immunohistological analyses of pancreata from patients with type 1 diabetes suggest distinct autoimmune islet β-cell pathology between those diagnosed at
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc19-0803