Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents

In present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), an opium alkaloid to yield 9 -hydroxy methyl and 9 -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis of 9-hydroxy methyl analogue of Nos was carried out by Blanc reaction...

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Veröffentlicht in:Scientific reports 2019-12, Vol.9 (1), p.19542-11, Article 19542
Hauptverfasser: Tomar, Vartika, Kumar, Neeraj, Tomar, Ravi, Sood, Damini, Dhiman, Neerupma, Dass, Sujata K., Prakash, Satya, Madan, Jitender, Chandra, Ramesh
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Sprache:eng
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Zusammenfassung:In present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), an opium alkaloid to yield 9 -hydroxy methyl and 9 -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis of 9-hydroxy methyl analogue of Nos was carried out by Blanc reaction and 9-carbaldehyde oxime was engineered by oxime formation method and characterized using FT-IR, 1 H NMR, 13 C NMR, mass spectroscopy, and so on techniques. In silico docking techniques informed that 9-hydroxy methyl and 9-carbaldehyde oxime analogues of Nos had higher binding energy score as compared to Nos. The IC50 of Nos was estimated to be 46.8 µM signficantly (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-55839-8