Can Combination MEK and Akt Inhibition Slay the Giant Congenital Nevus?

Can Combination MEK and Akt Inhibition Slay the Giant Congenital Nevus?

The clinical management of large and giant congenital melanocytic nevi (lgCMN) relies heavily upon iterative surgical procedures. In this issue Rouille et al. (2019) use lgCMN explants and a newly developed patient-derived xenograft model to show that the local administration of MEK and Akt inhibito...

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Veröffentlicht in:Journal of investigative dermatology 2019-09, Vol.139 (9), p.1857-1859
Hauptverfasser: Murphy, Brandon M., Burd, Christin E.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Nevus, Pigmented
Proto-Oncogene Proteins c-akt
Skin Neoplasms
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Zusammenfassung:The clinical management of large and giant congenital melanocytic nevi (lgCMN) relies heavily upon iterative surgical procedures. In this issue Rouille et al. (2019) use lgCMN explants and a newly developed patient-derived xenograft model to show that the local administration of MEK and Akt inhibitors limits the lgCMN proliferative potential. These findings, along with emerging reports, support continued investigation of targeted therapies in lgCMN.
ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2019.04.009