Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019

From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) strain were notified from four Western Pomerania medical facilities. The XDR produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol...

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Veröffentlicht in:Euro surveillance : bulletin européen sur les maladies transmissibles 2019-12, Vol.24 (50), p.1
Hauptverfasser: Haller, Sebastian, Kramer, Rolf, Becker, Karsten, Bohnert, Jürgen A, Eckmanns, Tim, Hans, Jörg B, Hecht, Jane, Heidecke, Claus-Dieter, Hübner, Nils-Olaf, Kramer, Axel, Klaper, Kathleen, Littmann, Martina, Marlinghaus, Lennart, Neumann, Bernd, Pfeifer, Yvonne, Pfennigwerth, Niels, Rogge, Simone, Schaufler, Katharina, Thürmer, Andrea, Werner, Guido, Gatermann, Sören
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Drug resistance
Epidemics
Rapid Communication
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Zusammenfassung:From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) strain were notified from four Western Pomerania medical facilities. The XDR produced carbapenemases NDM-1 and OXA-48, and was only susceptible to chloramphenicol, tigecycline and cefiderocol. Synergistic activity was observed for the combination of aztreonam plus ceftazidime-avibactam. Genomic analyses showed all isolates belonged to sequence type 307. Control measures and further investigations are ongoing.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2019.24.50.1900734