Polymer Nanocontainers: Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers (Adv. Sci. 24/2019)

Polymer Nanocontainers: Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers (Adv. Sci. 24/2019)

In article number 1901935, Volker Gerke, Bart Jan Ravoo, and co‐workers design novel polymer nanocontainers, based on redox‐responsive cyclodextrin amphiphiles mixed with phospholipids and encapsulated in a cystamine‐crosslinked polymer shell, to deliver amphiphilic cargo, specifically labeled phosp...

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Veröffentlicht in:Advanced science 2019-12, Vol.6 (24), p.n/a
Hauptverfasser: Vries, Wilke C., Kudruk, Sergej, Grill, David, Niehues, Maximilian, Matos, Anna Livia Linard, Wissing, Maren, Studer, Armido, Gerke, Volker, Ravoo, Bart Jan
Format: Artikel
Sprache:eng
Schlagworte:
disulfides
Inside Back Cover
intracellular delivery
lipids
liposomes
polymers
self‐assembly
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Zusammenfassung:In article number 1901935, Volker Gerke, Bart Jan Ravoo, and co‐workers design novel polymer nanocontainers, based on redox‐responsive cyclodextrin amphiphiles mixed with phospholipids and encapsulated in a cystamine‐crosslinked polymer shell, to deliver amphiphilic cargo, specifically labeled phospholipids, into human cells. Due to the redox‐sensitive cyclodextrin core and polymer shell, cargo is released inside the cell's reductive endosomal compartment.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201970146