Serum uromodulin inversely associates with aortic stiffness in youth with type 1 diabetes: A brief report from EMERALD study

Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potentia...

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Veröffentlicht in:	Journal of diabetes and its complications 2019-06, Vol.33 (6), p.434-436
Hauptverfasser:	Wiromrat, Pattara, Bjornstad, Petter, Roncal, Carlos, Cree-Green, Melanie, Baumgartner, Amy, Coe, Gregory, Reyes, Yesenia Garcia, Schäfer, Michal, Truong, Uyen, Pyle, Laura, Johnson, Richard J., Nadeau, Kristen J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Adult Age Aorta - diagnostic imaging Aorta - physiology Aortic stiffness Ascending aortic pulse wave velocity Atherosclerosis Biomarkers Biomarkers - blood Blood pressure Body mass index Cardiovascular Diseases - blood Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Child Coronary vessels Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - physiopathology Diabetic Angiopathies - blood Diabetic Angiopathies - etiology Diabetic Angiopathies - prevention & control Female Glomerular Filtration Rate Hispanic people Humans Insulin Male Metformin - therapeutic use Mortality Pediatrics Pulse Wave Analysis Relative area change Risk Factors Serum uromodulin Teenagers Treatment Outcome Triglycerides Type 1 diabetes Uromodulin - blood Vascular Stiffness - drug effects Young Adult
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Beschreibung
Zusammenfassung:	Youth with type 1 diabetes (T1D) carry greater cardiovascular disease (CVD) risk than their nondiabetic peers. Low serum uromodulin (SUMOD) associates with increased CVD mortality in adults. We found that T1D youth have low SUMOD. Lower SUMOD correlated with aortic stiffness, suggesting its potential as a CVD biomarker in T1D.
ISSN:	1056-8727 1873-460X
DOI:	10.1016/j.jdiacomp.2019.03.001