A Talented Duo: IFIT1 and IFIT3 Patrol Viral RNA Caps

Hosts respond to viral infection by expressing interferon-stimulated genes, of which IFITs are potent inhibitors of viral RNA translation. Johnson et al. (2018) solved the structure of the IFIT1-IFIT3 complex bound cap 0 RNA and explored their concerted antiviral activity. Hosts respond to viral inf...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2018-03, Vol.48 (3), p.474-476
Hauptverfasser:	Choi, Youn Jung, Bowman, James W., Jung, Jae U.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral activity Carrier Proteins - genetics Cryopyrin-Associated Periodic Syndromes Detonators Humans Infections Interferon Intracellular Signaling Peptides and Proteins Protein Biosynthesis Proteins Ribonucleic acid RNA RNA Caps RNA, Viral Viral infections Viruses West Nile virus
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Zusammenfassung:	Hosts respond to viral infection by expressing interferon-stimulated genes, of which IFITs are potent inhibitors of viral RNA translation. Johnson et al. (2018) solved the structure of the IFIT1-IFIT3 complex bound cap 0 RNA and explored their concerted antiviral activity. Hosts respond to viral infection by expressing interferon-stimulated genes, of which IFITs are potent inhibitors of viral RNA translation. Johnson et al. (2018) solved the structure of the IFIT1-IFIT3 complex bound cap 0 RNA and explored their concerted antiviral activity.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2018.03.001