Experience with non-vitamin K antagonists in the Netherlands: stories from both sides of the desk

[...]this lack of monitoring may come with new challenges and downsides, namely more inappropriate dosing and non-adherence [6]. [...]non-adherence to anticoagulants is likely to result in inappropriately low drug levels, and consequently, the cessation of the effect that they are intended for in the first place: to prevent thromboembolic complications [5, 6]. [...]the NOAC and VKA groups were not derived from the same population: users of VKAs were solely from a centre focussing on diagnostics located in Rotterdam, whereas the NOAC group was derived from a secondary/tertiary care hospital located in Nieuwegein [7]. [...]due to the differences in their offset of action and mechanism of producing an anticoagulant effect it’s unlikely that the reported non-adherence to both types of anticoagulants directly translates into a similarly reduced efficacy.