Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study

ABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive KT based on ABO incompatibility. We used data from the Korea Organ Transplantation Registry, a nationwide...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.18229-9, Article 18229
Hauptverfasser:	Kwon, Hyunwook, Kim, Jee Yeon, Kim, Dong Hyun, Ko, Youngmin, Choi, Ji Yoon, Shin, Sung, Jung, Joo Hee, Kim, Young Hoon, Han, Duck Jong
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 631/250/1854/2812 692/420/2780/2152/569 96/31 ABO Blood-Group System - immunology ABO system Antibodies Blood group A Blood Group Incompatibility - complications Blood Group Incompatibility - immunology Blood Grouping and Crossmatching Blood groups Clinical outcomes Cohort analysis Female Graft rejection Graft Rejection - epidemiology Graft Rejection - immunology Graft Survival - immunology Histocompatibility antigen HLA Histocompatibility testing HLA Antigens Humanities and Social Sciences Humans Kidney transplantation Kidney Transplantation - statistics & numerical data Kidney transplants Male Middle Aged multidisciplinary Multivariate analysis Nephropathy Republic of Korea Retrospective Studies Risk factors Science Science (multidisciplinary) Survival
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Zusammenfassung:	ABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive KT based on ABO incompatibility. We used data from the Korea Organ Transplantation Registry, a nationwide database, and a single-center registry. A total of 263 patients with positive XM were divided into an ABO compatible (ABOc) & XM positive (ABOc/XM+, n = 176) group and an ABOi & XM positive (ABOi/XM+, n = 87) group. The overall rejection rate one year after KT was significantly higher in the ABOi/XM+ group than in the ABOc/XM+ group ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-54397-3