Weight loss and breast cancer incidence in postmenopausal women
Background Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiativ...
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| Veröffentlicht in: | Cancer 2019-01, Vol.125 (2), p.205-212 |
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| creator | Chlebowski, Rowan T. Luo, Juhua Anderson, Garnet L. Barrington, Wendy Reding, Kerryn Simon, Michael S. Manson, JoAnn E. Rohan, Thomas E. Wactawski‐Wende, Jean Lane, Dorothy Strickler, Howard Mosaver‐Rahmani, Yasmin Freudenheim, Jo L. Saquib, Nazmus Stefanick, Marcia L. |
| description | Background
Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study.
Methods
Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable ( |
| doi_str_mv | 10.1002/cncr.31687 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6890496</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2166099494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4487-8a5700109b3c5fd724fa924406d44c12ec0265c13203e854de34209ae75fa87c3</originalsourceid><addsrcrecordid>eNp9kV1rFDEUhoNU7LZ64w8oA72RwqwnX5PkpiJLW4WiIIrehWzmTDtlNtkmMy7996bdtWgvepVzyMPDm7yEvKUwpwDsvQ8-zTlttHpBZhSMqoEKtkdmAKBrKfivfXKQ801ZFZP8FdnnwIzQtJmRDz-xv7oeqyHmXLnQVsuELo-Vd8Fjqvrg-xbLWKZqHfO4whDXbspuqDaxLK_Jy84NGd_szkPy4_zs--JTffn14vPi42XthdCq1k4qgJJtyb3sWsVE5wwTAppWCE8ZemCN9JQz4KilaJELBsahkp3TyvNDcrr1rqflCluPYUxusOvUr1y6s9H19v-b0F_bq_jbNtqAME0RvNsJUrydMI921WePw-ACxilbRqmikkvQBT1-gt7EKYXyvEI1DRgjjCjUyZbyqfxdwu4xDAV734u978U-9FLgo3_jP6J_iygA3QKbfsC7Z1R28WXxbSv9A0vJl5s</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2166099494</pqid></control><display><type>article</type><title>Weight loss and breast cancer incidence in postmenopausal women</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Chlebowski, Rowan T. ; Luo, Juhua ; Anderson, Garnet L. ; Barrington, Wendy ; Reding, Kerryn ; Simon, Michael S. ; Manson, JoAnn E. ; Rohan, Thomas E. ; Wactawski‐Wende, Jean ; Lane, Dorothy ; Strickler, Howard ; Mosaver‐Rahmani, Yasmin ; Freudenheim, Jo L. ; Saquib, Nazmus ; Stefanick, Marcia L.</creator><creatorcontrib>Chlebowski, Rowan T. ; Luo, Juhua ; Anderson, Garnet L. ; Barrington, Wendy ; Reding, Kerryn ; Simon, Michael S. ; Manson, JoAnn E. ; Rohan, Thomas E. ; Wactawski‐Wende, Jean ; Lane, Dorothy ; Strickler, Howard ; Mosaver‐Rahmani, Yasmin ; Freudenheim, Jo L. ; Saquib, Nazmus ; Stefanick, Marcia L.</creatorcontrib><description>Background
Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study.
Methods
Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self‐report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence.
Results
During a mean follow‐up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78‐0.98; P = .02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78‐0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93‐1.11) but was associated with higher triple‐negative breast cancer incidence (HR, 1.54; 95% CI, 1.16‐2.05).
Conclusions
Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.
A large prospective study of postmenopausal women reveals that women with a weight loss of ≥5% are at lower risk for invasive breast cancer compared with women who have stable weight.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.31687</identifier><identifier>PMID: 30294816</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Aged ; Body mass ; Body Mass Index ; Body size ; Body weight ; Body weight gain ; Body weight loss ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - pathology ; Cancer ; Confidence intervals ; Female ; Health risk assessment ; Health risks ; Hormone replacement therapy ; Humans ; Incidence ; Mammography ; Middle Aged ; Obesity ; Oncology ; Overweight - epidemiology ; Post-menopause ; Postmenopause - physiology ; Regression analysis ; Regression models ; Risk analysis ; Risk Factors ; Statistical analysis ; United States - epidemiology ; Weight Gain ; Weight Loss ; weight loss intentionality ; Weight reduction ; Women’s Health Initiative</subject><ispartof>Cancer, 2019-01, Vol.125 (2), p.205-212</ispartof><rights>2018 American Cancer Society</rights><rights>2018 American Cancer Society.</rights><rights>2019 American Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4487-8a5700109b3c5fd724fa924406d44c12ec0265c13203e854de34209ae75fa87c3</citedby><cites>FETCH-LOGICAL-c4487-8a5700109b3c5fd724fa924406d44c12ec0265c13203e854de34209ae75fa87c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.31687$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.31687$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30294816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chlebowski, Rowan T.</creatorcontrib><creatorcontrib>Luo, Juhua</creatorcontrib><creatorcontrib>Anderson, Garnet L.</creatorcontrib><creatorcontrib>Barrington, Wendy</creatorcontrib><creatorcontrib>Reding, Kerryn</creatorcontrib><creatorcontrib>Simon, Michael S.</creatorcontrib><creatorcontrib>Manson, JoAnn E.</creatorcontrib><creatorcontrib>Rohan, Thomas E.</creatorcontrib><creatorcontrib>Wactawski‐Wende, Jean</creatorcontrib><creatorcontrib>Lane, Dorothy</creatorcontrib><creatorcontrib>Strickler, Howard</creatorcontrib><creatorcontrib>Mosaver‐Rahmani, Yasmin</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><creatorcontrib>Saquib, Nazmus</creatorcontrib><creatorcontrib>Stefanick, Marcia L.</creatorcontrib><title>Weight loss and breast cancer incidence in postmenopausal women</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Background
Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study.
Methods
Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self‐report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence.
Results
During a mean follow‐up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78‐0.98; P = .02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78‐0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93‐1.11) but was associated with higher triple‐negative breast cancer incidence (HR, 1.54; 95% CI, 1.16‐2.05).
Conclusions
Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.
A large prospective study of postmenopausal women reveals that women with a weight loss of ≥5% are at lower risk for invasive breast cancer compared with women who have stable weight.</description><subject>Aged</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body weight gain</subject><subject>Body weight loss</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Hormone replacement therapy</subject><subject>Humans</subject><subject>Incidence</subject><subject>Mammography</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Oncology</subject><subject>Overweight - epidemiology</subject><subject>Post-menopause</subject><subject>Postmenopause - physiology</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>United States - epidemiology</subject><subject>Weight Gain</subject><subject>Weight Loss</subject><subject>weight loss intentionality</subject><subject>Weight reduction</subject><subject>Women’s Health Initiative</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoNU7LZ64w8oA72RwqwnX5PkpiJLW4WiIIrehWzmTDtlNtkmMy7996bdtWgvepVzyMPDm7yEvKUwpwDsvQ8-zTlttHpBZhSMqoEKtkdmAKBrKfivfXKQ801ZFZP8FdnnwIzQtJmRDz-xv7oeqyHmXLnQVsuELo-Vd8Fjqvrg-xbLWKZqHfO4whDXbspuqDaxLK_Jy84NGd_szkPy4_zs--JTffn14vPi42XthdCq1k4qgJJtyb3sWsVE5wwTAppWCE8ZemCN9JQz4KilaJELBsahkp3TyvNDcrr1rqflCluPYUxusOvUr1y6s9H19v-b0F_bq_jbNtqAME0RvNsJUrydMI921WePw-ACxilbRqmikkvQBT1-gt7EKYXyvEI1DRgjjCjUyZbyqfxdwu4xDAV734u978U-9FLgo3_jP6J_iygA3QKbfsC7Z1R28WXxbSv9A0vJl5s</recordid><startdate>20190115</startdate><enddate>20190115</enddate><creator>Chlebowski, Rowan T.</creator><creator>Luo, Juhua</creator><creator>Anderson, Garnet L.</creator><creator>Barrington, Wendy</creator><creator>Reding, Kerryn</creator><creator>Simon, Michael S.</creator><creator>Manson, JoAnn E.</creator><creator>Rohan, Thomas E.</creator><creator>Wactawski‐Wende, Jean</creator><creator>Lane, Dorothy</creator><creator>Strickler, Howard</creator><creator>Mosaver‐Rahmani, Yasmin</creator><creator>Freudenheim, Jo L.</creator><creator>Saquib, Nazmus</creator><creator>Stefanick, Marcia L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190115</creationdate><title>Weight loss and breast cancer incidence in postmenopausal women</title><author>Chlebowski, Rowan T. ; Luo, Juhua ; Anderson, Garnet L. ; Barrington, Wendy ; Reding, Kerryn ; Simon, Michael S. ; Manson, JoAnn E. ; Rohan, Thomas E. ; Wactawski‐Wende, Jean ; Lane, Dorothy ; Strickler, Howard ; Mosaver‐Rahmani, Yasmin ; Freudenheim, Jo L. ; Saquib, Nazmus ; Stefanick, Marcia L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4487-8a5700109b3c5fd724fa924406d44c12ec0265c13203e854de34209ae75fa87c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body weight gain</topic><topic>Body weight loss</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer</topic><topic>Confidence intervals</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Health risks</topic><topic>Hormone replacement therapy</topic><topic>Humans</topic><topic>Incidence</topic><topic>Mammography</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Oncology</topic><topic>Overweight - epidemiology</topic><topic>Post-menopause</topic><topic>Postmenopause - physiology</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Statistical analysis</topic><topic>United States - epidemiology</topic><topic>Weight Gain</topic><topic>Weight Loss</topic><topic>weight loss intentionality</topic><topic>Weight reduction</topic><topic>Women’s Health Initiative</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chlebowski, Rowan T.</creatorcontrib><creatorcontrib>Luo, Juhua</creatorcontrib><creatorcontrib>Anderson, Garnet L.</creatorcontrib><creatorcontrib>Barrington, Wendy</creatorcontrib><creatorcontrib>Reding, Kerryn</creatorcontrib><creatorcontrib>Simon, Michael S.</creatorcontrib><creatorcontrib>Manson, JoAnn E.</creatorcontrib><creatorcontrib>Rohan, Thomas E.</creatorcontrib><creatorcontrib>Wactawski‐Wende, Jean</creatorcontrib><creatorcontrib>Lane, Dorothy</creatorcontrib><creatorcontrib>Strickler, Howard</creatorcontrib><creatorcontrib>Mosaver‐Rahmani, Yasmin</creatorcontrib><creatorcontrib>Freudenheim, Jo L.</creatorcontrib><creatorcontrib>Saquib, Nazmus</creatorcontrib><creatorcontrib>Stefanick, Marcia L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chlebowski, Rowan T.</au><au>Luo, Juhua</au><au>Anderson, Garnet L.</au><au>Barrington, Wendy</au><au>Reding, Kerryn</au><au>Simon, Michael S.</au><au>Manson, JoAnn E.</au><au>Rohan, Thomas E.</au><au>Wactawski‐Wende, Jean</au><au>Lane, Dorothy</au><au>Strickler, Howard</au><au>Mosaver‐Rahmani, Yasmin</au><au>Freudenheim, Jo L.</au><au>Saquib, Nazmus</au><au>Stefanick, Marcia L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weight loss and breast cancer incidence in postmenopausal women</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2019-01-15</date><risdate>2019</risdate><volume>125</volume><issue>2</issue><spage>205</spage><epage>212</epage><pages>205-212</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Background
Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study.
Methods
Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (<5%), loss (≥5%), or gain (≥5%) with further assessment of weight loss intentionality by self‐report. Multivariable Cox proportional hazard regression models were used to evaluate relationships between weight change and subsequent breast cancer incidence.
Results
During a mean follow‐up of 11.4 years with 3061 incident breast cancers, women with weight loss (n = 8175) had a significantly lower risk of breast cancer compared with women whose weight remained stable (n = 41,139) (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.78‐0.98; P = .02) with no interaction by BMI. Adjustment for mammography did not alter findings (HR, 0.88; 95% CI, 0.78‐0.99) with no significant difference by weight loss intentionality. Weight gain (≥5%) (n = 12,021) was not associated with breast cancer risk (HR, 1.02; 95% CI, 0.93‐1.11) but was associated with higher triple‐negative breast cancer incidence (HR, 1.54; 95% CI, 1.16‐2.05).
Conclusions
Postmenopausal women who lose weight have lower breast cancer risk than those with stable weight. These findings suggest that postmenopausal women who lose weight may reduce their breast cancer risk.
A large prospective study of postmenopausal women reveals that women with a weight loss of ≥5% are at lower risk for invasive breast cancer compared with women who have stable weight.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30294816</pmid><doi>10.1002/cncr.31687</doi><tpages>0</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Aged Body mass Body Mass Index Body size Body weight Body weight gain Body weight loss Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - pathology Cancer Confidence intervals Female Health risk assessment Health risks Hormone replacement therapy Humans Incidence Mammography Middle Aged Obesity Oncology Overweight - epidemiology Post-menopause Postmenopause - physiology Regression analysis Regression models Risk analysis Risk Factors Statistical analysis United States - epidemiology Weight Gain Weight Loss weight loss intentionality Weight reduction Women’s Health Initiative |
| title | Weight loss and breast cancer incidence in postmenopausal women |
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