Weight loss and breast cancer incidence in postmenopausal women

Weight loss and breast cancer incidence in postmenopausal women

Background Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiativ...

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Veröffentlicht in:Cancer 2019-01, Vol.125 (2), p.205-212
Hauptverfasser: Chlebowski, Rowan T., Luo, Juhua, Anderson, Garnet L., Barrington, Wendy, Reding, Kerryn, Simon, Michael S., Manson, JoAnn E., Rohan, Thomas E., Wactawski‐Wende, Jean, Lane, Dorothy, Strickler, Howard, Mosaver‐Rahmani, Yasmin, Freudenheim, Jo L., Saquib, Nazmus, Stefanick, Marcia L.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Body mass
Body Mass Index
Body size
Body weight
Body weight gain
Body weight loss
Breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - pathology
Cancer
Confidence intervals
Female
Health risk assessment
Health risks
Hormone replacement therapy
Humans
Incidence
Mammography
Middle Aged
Obesity
Oncology
Overweight - epidemiology
Post-menopause
Postmenopause - physiology
Regression analysis
Regression models
Risk analysis
Risk Factors
Statistical analysis
United States - epidemiology
Weight Gain
Weight Loss
weight loss intentionality
Weight reduction
Women’s Health Initiative
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Zusammenfassung:Background Although obesity is an established risk factor for postmenopausal breast cancer, the results of weight loss and breast cancer studies are inconsistent. Therefore, we evaluated associations between weight change and breast cancer risk in postmenopausal women in the Women’s Health Initiative Observational Study. Methods Postmenopausal women (n = 61,335) who had no prior breast cancer and a normal mammogram had body weight and height measured and body mass index (BMI) calculated at baseline and year 3. Weight change at year 3 was categorized as stable (
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.31687