Acyl ethanolamides in Diabetes and Diabetic Nephropathy: Novel targets from untargeted plasma metabolomic profiles of South Asian Indian men

The pathophysiology of diabetic nephropathy (DN) in type 2 diabetes (T2D) patients is minimally understood. We compared untargeted high-resolution accurate mass (HRAM) orbitrap-based plasma metabolomic profiles of 31 T2D-DN (with estimated glomerular filtration rate ≤80 mL/min/1.73 m 2 ), 29 T2D and...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.18117-11, Article 18117
Hauptverfasser:	Devi, Sarita, Nongkhlaw, Bajanai, Limesh, M., Pasanna, Roshni M., Thomas, Tinku, Kuriyan, Rebecca, Kurpad, Anura V., Mukhopadhyay, Arpita
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/443/319/320 692/699/2743/137/138 82 82/58 Acetylcholine Adult Agonists Amino acids Amino Acids - blood Amino Acids - metabolism Biomarkers - blood Case-Control Studies Cortisol Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - metabolism Diabetic Nephropathies - diagnosis Diabetic Nephropathies - metabolism Diabetic nephropathy Glomerular Filtration Rate Glucose Glucose tolerance Humanities and Social Sciences Humans Imidazoles - blood India Lactates - blood Male Metabolites Metabolomics Middle Aged multidisciplinary Nephropathy Ornithine - analogs & derivatives Ornithine - blood Renal function Science Science (multidisciplinary) Socioeconomic Factors Variance analysis
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Zusammenfassung:	The pathophysiology of diabetic nephropathy (DN) in type 2 diabetes (T2D) patients is minimally understood. We compared untargeted high-resolution accurate mass (HRAM) orbitrap-based plasma metabolomic profiles of 31 T2D-DN (with estimated glomerular filtration rate ≤80 mL/min/1.73 m 2 ), 29 T2D and 30 normal glucose tolerance (NGT) Indian men. Of the 939 plasma metabolites that were differentially abundant amongst the NGT, T2D and T2D-DN (ANOVA, False Discovery Rate – FDR adjusted p- value
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-54584-2