Chronic adolescent stress sex-specifically alters central and peripheral neuro-immune reactivity in rats

•Chronic adolescent stress in rats primes neuroimmune reactivity in adulthood.•Adolescent stress potentiated NFκB-related genes post-LPS in the adult hippocampus.•Hippocampal IL1B post-LPS was enhanced by adolescent stress in adult females only.•Adolescent stress enhanced peripheral immune outcomes...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2019-02, Vol.76, p.248-257
Hauptverfasser:	Bekhbat, Mandakh, Howell, Paul A., Rowson, Sydney A., Kelly, Sean D., Tansey, Malú G., Neigh, Gretchen N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescence Age Factors Animals Anxiety - metabolism Anxiety Disorders Central Nervous System - metabolism Corticosterone - blood Cytokines - metabolism Depression - metabolism Depressive Disorder - metabolism Female Hippocampus - metabolism Hypothalamo-Hypophyseal System - metabolism IL-1β IL-6 Inflammation - metabolism Interleukin-1beta - metabolism Lipopolysaccharides - pharmacology Male Metabolism, Inborn Errors Neuroimmunomodulation - physiology Neuroinflammation NF-kappa B - metabolism NFκB Pituitary-Adrenal System - metabolism Rat Rats Rats, Wistar Receptors, Glucocorticoid - deficiency Sex differences Sex Factors Stress Stress, Psychological - metabolism Stress, Psychological - physiopathology TNF-α
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