Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery
Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative ho...
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| Veröffentlicht in: | Disease markers 2019, Vol.2019 (2019), p.1-7 |
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| creator | Yang, Peiliang Yang, Manqiu Luo, Weihong Fang, Fan Yang, Xiaobing |
| description | Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and UACR) were measured at time of AKI clinical diagnosis. The primary outcome is the progression of AKI after cardiac surgery, defined as worsening of AKI stage (stage 1 to either stage 2 or stage 3 or from stage 2 to stage 3). Results. A level of uMMP‐7>7.8 μg/g Cr at time of AKI diagnosis conveyed an 8-fold risk of AKI progression as compared to those with uMMP‐7 |
| doi_str_mv | 10.1155/2019/9217571 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6885836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A614078725</galeid><sourcerecordid>A614078725</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-f539fc340f6c20223e64c002071a10348748919b42356bc221a5a4e98310f3853</originalsourceid><addsrcrecordid>eNqNkc1rFDEYh4Modq3ePMuAF0HHvvlOLsKy-FFssaA9eArZTLJNmZ2syYza_94Mu7bqyVPgfR-evD9-CD3F8Bpjzk8IYH2iCZZc4ntogZXkrRIU7qMFEKlaIAyO0KNSrgEw0Uw_REcUKyIFUwv09TLHweab5tyOOf5szv1o-z7tchp9XRTfysYOXXORfRfdGNPQpNAsP57WSdpkX8o8ukhlbFY2d9G65vOUNz7fPEYPgu2Lf3J4j9Hlu7dfVh_as0_vT1fLs9Yxrcc2cKqDowyCcAQIoV4wB0BAYouBMiWZ0livGaFcrB0h2HLLvFYUQ6CK02P0Zu_dTeut75wfxmx7s8txW3OZZKP5ezPEK7NJ341QiisqquDFQZDTt8mX0Wxjcb7v7eDTVAyhhFMQTEBFn_-DXqcpDzXeTIHGWBN6R21s700cQqr_ullqlgIzkEqS-e5Xe8rlVEr24fZkDGZu1szNmkOzFX_2Z8xb-HeVFXi5B67i0Nkf8T91vjI-2DsaM6mFor8AD_iyLg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2320911923</pqid></control><display><type>article</type><title>Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery</title><source>MEDLINE</source><source>Wiley-Blackwell Open Access Titles</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yang, Peiliang ; Yang, Manqiu ; Luo, Weihong ; Fang, Fan ; Yang, Xiaobing</creator><contributor>Chadjichristos, Christos ; Christos Chadjichristos</contributor><creatorcontrib>Yang, Peiliang ; Yang, Manqiu ; Luo, Weihong ; Fang, Fan ; Yang, Xiaobing ; Chadjichristos, Christos ; Christos Chadjichristos</creatorcontrib><description>Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and UACR) were measured at time of AKI clinical diagnosis. The primary outcome is the progression of AKI after cardiac surgery, defined as worsening of AKI stage (stage 1 to either stage 2 or stage 3 or from stage 2 to stage 3). Results. A level of uMMP‐7>7.8 μg/g Cr at time of AKI diagnosis conveyed an 8-fold risk of AKI progression as compared to those with uMMP‐7<2.7 μg/g after adjusting for clinical risk factors. The performance of uMMP-7 for predicting progressive AKI was good with an AUC of 0.80. The combination of uMMP-7 and IL-18 produces the greatest AUC for predicting progressive AKI. Addition of uMMP-7 to the clinical risk factor model significantly improved risk reclassification for AKI progression. Conclusions. uMMP-7, measured at time of AKI clinical diagnosis, is a novel biomarker for predicting the progression of AKI after cardiac surgery. Adding uMMP-7 to the clinical risk factor model may be used as a noninvasive approach to identify a subpopulation that is at high risk for progressive AKI after cardiac surgery.</description><identifier>ISSN: 0278-0240</identifier><identifier>EISSN: 1875-8630</identifier><identifier>DOI: 10.1155/2019/9217571</identifier><identifier>PMID: 31827648</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acute Kidney Injury - diagnosis ; Acute Kidney Injury - etiology ; Acute Kidney Injury - urine ; Analysis ; Biomarkers ; Biomarkers - urine ; Cardiac Surgical Procedures - adverse effects ; Chromium ; Diagnosis ; Female ; Follow-Up Studies ; Heart ; Heart Diseases - pathology ; Heart Diseases - surgery ; Heart surgery ; Hemodialysis ; Hospitals ; Humans ; Interleukin 18 ; Kidney diseases ; Male ; Matrilysin ; Matrix metalloproteinase ; Matrix Metalloproteinase 7 - urine ; Matrix metalloproteinases ; Medical research ; Medicine, Experimental ; Metalloproteinase ; Middle Aged ; Mortality ; Nephrology ; Patients ; Postoperative Complications ; Predictions ; Prognosis ; Prospective Studies ; Reclassification ; Risk analysis ; Risk Factors ; Surgery ; Time measurement ; Urine ; Variables</subject><ispartof>Disease markers, 2019, Vol.2019 (2019), p.1-7</ispartof><rights>Copyright © 2019 Fan Fang et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Fan Fang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Fan Fang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-f539fc340f6c20223e64c002071a10348748919b42356bc221a5a4e98310f3853</citedby><cites>FETCH-LOGICAL-c499t-f539fc340f6c20223e64c002071a10348748919b42356bc221a5a4e98310f3853</cites><orcidid>0000-0003-4950-4245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885836/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885836/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4022,27922,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31827648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chadjichristos, Christos</contributor><contributor>Christos Chadjichristos</contributor><creatorcontrib>Yang, Peiliang</creatorcontrib><creatorcontrib>Yang, Manqiu</creatorcontrib><creatorcontrib>Luo, Weihong</creatorcontrib><creatorcontrib>Fang, Fan</creatorcontrib><creatorcontrib>Yang, Xiaobing</creatorcontrib><title>Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery</title><title>Disease markers</title><addtitle>Dis Markers</addtitle><description>Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and UACR) were measured at time of AKI clinical diagnosis. The primary outcome is the progression of AKI after cardiac surgery, defined as worsening of AKI stage (stage 1 to either stage 2 or stage 3 or from stage 2 to stage 3). Results. A level of uMMP‐7>7.8 μg/g Cr at time of AKI diagnosis conveyed an 8-fold risk of AKI progression as compared to those with uMMP‐7<2.7 μg/g after adjusting for clinical risk factors. The performance of uMMP-7 for predicting progressive AKI was good with an AUC of 0.80. The combination of uMMP-7 and IL-18 produces the greatest AUC for predicting progressive AKI. Addition of uMMP-7 to the clinical risk factor model significantly improved risk reclassification for AKI progression. Conclusions. uMMP-7, measured at time of AKI clinical diagnosis, is a novel biomarker for predicting the progression of AKI after cardiac surgery. Adding uMMP-7 to the clinical risk factor model may be used as a noninvasive approach to identify a subpopulation that is at high risk for progressive AKI after cardiac surgery.</description><subject>Acute Kidney Injury - diagnosis</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - urine</subject><subject>Analysis</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Chromium</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart Diseases - pathology</subject><subject>Heart Diseases - surgery</subject><subject>Heart surgery</subject><subject>Hemodialysis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Interleukin 18</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Matrilysin</subject><subject>Matrix metalloproteinase</subject><subject>Matrix Metalloproteinase 7 - urine</subject><subject>Matrix metalloproteinases</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metalloproteinase</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Patients</subject><subject>Postoperative Complications</subject><subject>Predictions</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Reclassification</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Time measurement</subject><subject>Urine</subject><subject>Variables</subject><issn>0278-0240</issn><issn>1875-8630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc1rFDEYh4Modq3ePMuAF0HHvvlOLsKy-FFssaA9eArZTLJNmZ2syYza_94Mu7bqyVPgfR-evD9-CD3F8Bpjzk8IYH2iCZZc4ntogZXkrRIU7qMFEKlaIAyO0KNSrgEw0Uw_REcUKyIFUwv09TLHweab5tyOOf5szv1o-z7tchp9XRTfysYOXXORfRfdGNPQpNAsP57WSdpkX8o8ukhlbFY2d9G65vOUNz7fPEYPgu2Lf3J4j9Hlu7dfVh_as0_vT1fLs9Yxrcc2cKqDowyCcAQIoV4wB0BAYouBMiWZ0livGaFcrB0h2HLLvFYUQ6CK02P0Zu_dTeut75wfxmx7s8txW3OZZKP5ezPEK7NJ341QiisqquDFQZDTt8mX0Wxjcb7v7eDTVAyhhFMQTEBFn_-DXqcpDzXeTIHGWBN6R21s700cQqr_ullqlgIzkEqS-e5Xe8rlVEr24fZkDGZu1szNmkOzFX_2Z8xb-HeVFXi5B67i0Nkf8T91vjI-2DsaM6mFor8AD_iyLg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Yang, Peiliang</creator><creator>Yang, Manqiu</creator><creator>Luo, Weihong</creator><creator>Fang, Fan</creator><creator>Yang, Xiaobing</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4950-4245</orcidid></search><sort><creationdate>2019</creationdate><title>Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery</title><author>Yang, Peiliang ; Yang, Manqiu ; Luo, Weihong ; Fang, Fan ; Yang, Xiaobing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-f539fc340f6c20223e64c002071a10348748919b42356bc221a5a4e98310f3853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acute Kidney Injury - diagnosis</topic><topic>Acute Kidney Injury - etiology</topic><topic>Acute Kidney Injury - urine</topic><topic>Analysis</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Chromium</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart Diseases - pathology</topic><topic>Heart Diseases - surgery</topic><topic>Heart surgery</topic><topic>Hemodialysis</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Interleukin 18</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Matrilysin</topic><topic>Matrix metalloproteinase</topic><topic>Matrix Metalloproteinase 7 - urine</topic><topic>Matrix metalloproteinases</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metalloproteinase</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Patients</topic><topic>Postoperative Complications</topic><topic>Predictions</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Reclassification</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Time measurement</topic><topic>Urine</topic><topic>Variables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Peiliang</creatorcontrib><creatorcontrib>Yang, Manqiu</creatorcontrib><creatorcontrib>Luo, Weihong</creatorcontrib><creatorcontrib>Fang, Fan</creatorcontrib><creatorcontrib>Yang, Xiaobing</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Disease markers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Peiliang</au><au>Yang, Manqiu</au><au>Luo, Weihong</au><au>Fang, Fan</au><au>Yang, Xiaobing</au><au>Chadjichristos, Christos</au><au>Christos Chadjichristos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery</atitle><jtitle>Disease markers</jtitle><addtitle>Dis Markers</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0278-0240</issn><eissn>1875-8630</eissn><abstract>Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and UACR) were measured at time of AKI clinical diagnosis. The primary outcome is the progression of AKI after cardiac surgery, defined as worsening of AKI stage (stage 1 to either stage 2 or stage 3 or from stage 2 to stage 3). Results. A level of uMMP‐7>7.8 μg/g Cr at time of AKI diagnosis conveyed an 8-fold risk of AKI progression as compared to those with uMMP‐7<2.7 μg/g after adjusting for clinical risk factors. The performance of uMMP-7 for predicting progressive AKI was good with an AUC of 0.80. The combination of uMMP-7 and IL-18 produces the greatest AUC for predicting progressive AKI. Addition of uMMP-7 to the clinical risk factor model significantly improved risk reclassification for AKI progression. Conclusions. uMMP-7, measured at time of AKI clinical diagnosis, is a novel biomarker for predicting the progression of AKI after cardiac surgery. Adding uMMP-7 to the clinical risk factor model may be used as a noninvasive approach to identify a subpopulation that is at high risk for progressive AKI after cardiac surgery.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31827648</pmid><doi>10.1155/2019/9217571</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4950-4245</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Kidney Injury - diagnosis Acute Kidney Injury - etiology Acute Kidney Injury - urine Analysis Biomarkers Biomarkers - urine Cardiac Surgical Procedures - adverse effects Chromium Diagnosis Female Follow-Up Studies Heart Heart Diseases - pathology Heart Diseases - surgery Heart surgery Hemodialysis Hospitals Humans Interleukin 18 Kidney diseases Male Matrilysin Matrix metalloproteinase Matrix Metalloproteinase 7 - urine Matrix metalloproteinases Medical research Medicine, Experimental Metalloproteinase Middle Aged Mortality Nephrology Patients Postoperative Complications Predictions Prognosis Prospective Studies Reclassification Risk analysis Risk Factors Surgery Time measurement Urine Variables |
| title | Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery |
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