Urinary Matrix Metalloproteinase-7 and Prediction of AKI Progression Post Cardiac Surgery

Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative ho...

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Veröffentlicht in:Disease markers 2019, Vol.2019 (2019), p.1-7
Hauptverfasser: Yang, Peiliang, Yang, Manqiu, Luo, Weihong, Fang, Fan, Yang, Xiaobing
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Sprache:eng
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Zusammenfassung:Aims. Early detection of patients at high risk for progressive acute kidney injury (AKI) after cardiac surgery remains a major challenge. We aim to evaluate the utility of urinary matrix metalloproteinase-7 (uMMP-7) and other reported biomarkers for predicting AKI progression during postoperative hospital stay. Methods. We conducted a prospective, multicenter cohort study in 121 adult patients with stage 1 or 2 AKI after cardiac surgery. uMMP-7 and other well-reported biomarkers (uIL-18, uNGAL, and UACR) were measured at time of AKI clinical diagnosis. The primary outcome is the progression of AKI after cardiac surgery, defined as worsening of AKI stage (stage 1 to either stage 2 or stage 3 or from stage 2 to stage 3). Results. A level of uMMP‐7>7.8 μg/g Cr at time of AKI diagnosis conveyed an 8-fold risk of AKI progression as compared to those with uMMP‐7
ISSN:0278-0240
1875-8630
DOI:10.1155/2019/9217571