Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women

Metabolic obesity phenotypes and risk of colorectal cancer in postmenopausal women

Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model‐insulin...

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Veröffentlicht in:International journal of cancer 2018-08, Vol.143 (3), p.543-551
Hauptverfasser: Kabat, Geoffrey C., Kim, Mimi Y., Stefanick, Marcia, Ho, Gloria Y.F., Lane, Dorothy S., Odegaard, Andrew O., Simon, Michael S., Bea, Jennifer W., Luo, Juhua, Wassertheil‐Smoller, Sylvia, Rohan, Thomas E.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Bioindicators
Biomarkers
Body mass
Body Mass Index
Body weight
Cancer
Carcinogenesis
Circumferences
Colorectal cancer
colorectal cancer risk
Colorectal carcinoma
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - etiology
Cytokines
Female
Follow-Up Studies
Genotype & phenotype
Health risk assessment
Health risks
HOMA‐IR
Homeostasis
Hormone replacement therapy
Humans
Insulin
Insulin Resistance
Medical research
Metabolic disorders
metabolic status
Metabolic syndrome
Metabolic Syndrome - complications
Metabolic Syndrome - metabolism
Middle Aged
Obesity
Obesity - complications
Obesity - metabolism
Odds Ratio
Overweight
Phenotype
Phenotypes
Population Surveillance
Post-menopause
postmenopausal women
Postmenopause
Risk Assessment
Risk Factors
waist circumference
Womens health
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Zusammenfassung:Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model‐insulin resistance (HOMA‐IR—a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross‐classified by BMI (18.5–
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31345