Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias
Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages...
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| Veröffentlicht in: | Scientific reports 2019-11, Vol.9 (1), p.17329-7, Article 17329 |
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| description | Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages (7 years of disease duration). Overall, 186 patients with probable MSA-C and 117 with genetically confirmed SCAs were included. Hot cross bun (HCB) signs and middle cerebellar peduncle (MCP) hyperintensities were exclusively prevalent in MSA-C compared to SCAs at |
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We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages (<3, 3–7, and >7 years of disease duration). Overall, 186 patients with probable MSA-C and 117 with genetically confirmed SCAs were included. Hot cross bun (HCB) signs and middle cerebellar peduncle (MCP) hyperintensities were exclusively prevalent in MSA-C compared to SCAs at <3 years (HCB, 44.6% versus 0.9%; MCP hyperintensities, 38.3% versus 0.9%, respectively). Sensitivity, specificity, and positive predictive value (PPV) for HCB signs to differentiate MSA-C from SCAs were 45%, 99%, and 99% and those for MCP hyperintensities were 68%, 99%, and 99%, respectively; considering both HCB signs and MCP hyperintensities, specificity and PPV were 100%. However, the differential value of MRI signs decreased over time. MCP widths were smaller and showed more significant decrease in MSA-C than in SCAs. In conclusion, pontine and MCP changes were exclusively prominent in early stage MSA-C rather than in SCAs. Therefore, we should consider disease duration when interpreting pontine and MCP changes in brain MRIs, which will help better differentiate MSA-C and SCAs.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-53980-y</identifier><identifier>PMID: 31758059</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/617/375/2014 ; 692/617/375/364 ; Adult ; Aged ; Atrophy ; Cerebellum ; Cerebellum - diagnostic imaging ; Diagnosis, Differential ; Female ; Humanities and Social Sciences ; Humans ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; multidisciplinary ; Multiple System Atrophy - diagnostic imaging ; Neuroimaging ; NMR ; Nuclear magnetic resonance ; Phenotype ; Phenotypes ; Retrospective Studies ; Science ; Science (multidisciplinary) ; Sensitivity and Specificity ; Spinocerebellar ataxia ; Spinocerebellar Ataxias - diagnostic imaging</subject><ispartof>Scientific reports, 2019-11, Vol.9 (1), p.17329-7, Article 17329</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-2c71ae6fe074846f695f6841af75dfcaa5a52dc550b9b66fc377d6a3b5342f523</citedby><cites>FETCH-LOGICAL-c474t-2c71ae6fe074846f695f6841af75dfcaa5a52dc550b9b66fc377d6a3b5342f523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874541/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874541/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31758059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Minkyeong</creatorcontrib><creatorcontrib>Ahn, Jong Hyeon</creatorcontrib><creatorcontrib>Cho, Yoonsu</creatorcontrib><creatorcontrib>Kim, Ji Sun</creatorcontrib><creatorcontrib>Youn, Jinyoung</creatorcontrib><creatorcontrib>Cho, Jin Whan</creatorcontrib><title>Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages (<3, 3–7, and >7 years of disease duration). Overall, 186 patients with probable MSA-C and 117 with genetically confirmed SCAs were included. Hot cross bun (HCB) signs and middle cerebellar peduncle (MCP) hyperintensities were exclusively prevalent in MSA-C compared to SCAs at <3 years (HCB, 44.6% versus 0.9%; MCP hyperintensities, 38.3% versus 0.9%, respectively). Sensitivity, specificity, and positive predictive value (PPV) for HCB signs to differentiate MSA-C from SCAs were 45%, 99%, and 99% and those for MCP hyperintensities were 68%, 99%, and 99%, respectively; considering both HCB signs and MCP hyperintensities, specificity and PPV were 100%. However, the differential value of MRI signs decreased over time. MCP widths were smaller and showed more significant decrease in MSA-C than in SCAs. In conclusion, pontine and MCP changes were exclusively prominent in early stage MSA-C rather than in SCAs. Therefore, we should consider disease duration when interpreting pontine and MCP changes in brain MRIs, which will help better differentiate MSA-C and SCAs.</description><subject>692/617/375/2014</subject><subject>692/617/375/364</subject><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Cerebellum</subject><subject>Cerebellum - diagnostic imaging</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Multiple System Atrophy - diagnostic imaging</subject><subject>Neuroimaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Retrospective Studies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sensitivity and Specificity</subject><subject>Spinocerebellar ataxia</subject><subject>Spinocerebellar Ataxias - diagnostic imaging</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhSMEolXpH2CBLLFhE_A7yQYJladUiQ2srRvnesZVxg52UjVbfjmemVIGFnhjy-fzsY9PVT1n9DWjon2TJVNdW1PW1Up0La3XR9U5p1LVXHD--GR9Vl3mfEPLULyTrHtanQnWqJaq7rz6-d47hwnD7GEktzAuSKIjfQIfyA42AWdvScIcAwSLxJc9HzZkry7j7KcRSV7zjDsCc4rTdiW22PU4jpDItMUQ53VCAmEgefIhnqgww52H_Kx64mDMeHk_X1TfP374dvW5vv766cvVu-vaykbONbcNA9QOaSNbqZ3ulNOtZOAaNTgLoEDxwSpF-67X2lnRNIMG0SshuVNcXFRvj77T0u9wsCVzgtFMqWRKq4ngzd9K8FuzibdGt41UkhWDV_cGKf5YMM9m57PdZwkYl2z44VsVZW1BX_6D3sQlhRLvQFGhO9oUih8pm2LOCd3DYxg1-5bNsWVTWjaHls1aDr04jfFw5HenBRBHIBcpbDD9ufs_tr8A_V63WQ</recordid><startdate>20191122</startdate><enddate>20191122</enddate><creator>Kim, Minkyeong</creator><creator>Ahn, Jong Hyeon</creator><creator>Cho, Yoonsu</creator><creator>Kim, Ji Sun</creator><creator>Youn, Jinyoung</creator><creator>Cho, Jin Whan</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191122</creationdate><title>Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias</title><author>Kim, Minkyeong ; Ahn, Jong Hyeon ; Cho, Yoonsu ; Kim, Ji Sun ; Youn, Jinyoung ; Cho, Jin Whan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-2c71ae6fe074846f695f6841af75dfcaa5a52dc550b9b66fc377d6a3b5342f523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>692/617/375/2014</topic><topic>692/617/375/364</topic><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Cerebellum</topic><topic>Cerebellum - diagnostic imaging</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Multiple System Atrophy - diagnostic imaging</topic><topic>Neuroimaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Retrospective Studies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sensitivity and Specificity</topic><topic>Spinocerebellar ataxia</topic><topic>Spinocerebellar Ataxias - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Minkyeong</creatorcontrib><creatorcontrib>Ahn, Jong Hyeon</creatorcontrib><creatorcontrib>Cho, Yoonsu</creatorcontrib><creatorcontrib>Kim, Ji Sun</creatorcontrib><creatorcontrib>Youn, Jinyoung</creatorcontrib><creatorcontrib>Cho, Jin Whan</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Minkyeong</au><au>Ahn, Jong Hyeon</au><au>Cho, Yoonsu</au><au>Kim, Ji Sun</au><au>Youn, Jinyoung</au><au>Cho, Jin Whan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-11-22</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>17329</spage><epage>7</epage><pages>17329-7</pages><artnum>17329</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages (<3, 3–7, and >7 years of disease duration). Overall, 186 patients with probable MSA-C and 117 with genetically confirmed SCAs were included. Hot cross bun (HCB) signs and middle cerebellar peduncle (MCP) hyperintensities were exclusively prevalent in MSA-C compared to SCAs at <3 years (HCB, 44.6% versus 0.9%; MCP hyperintensities, 38.3% versus 0.9%, respectively). Sensitivity, specificity, and positive predictive value (PPV) for HCB signs to differentiate MSA-C from SCAs were 45%, 99%, and 99% and those for MCP hyperintensities were 68%, 99%, and 99%, respectively; considering both HCB signs and MCP hyperintensities, specificity and PPV were 100%. However, the differential value of MRI signs decreased over time. MCP widths were smaller and showed more significant decrease in MSA-C than in SCAs. In conclusion, pontine and MCP changes were exclusively prominent in early stage MSA-C rather than in SCAs. Therefore, we should consider disease duration when interpreting pontine and MCP changes in brain MRIs, which will help better differentiate MSA-C and SCAs.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31758059</pmid><doi>10.1038/s41598-019-53980-y</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/617/375/2014 692/617/375/364 Adult Aged Atrophy Cerebellum Cerebellum - diagnostic imaging Diagnosis, Differential Female Humanities and Social Sciences Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged multidisciplinary Multiple System Atrophy - diagnostic imaging Neuroimaging NMR Nuclear magnetic resonance Phenotype Phenotypes Retrospective Studies Science Science (multidisciplinary) Sensitivity and Specificity Spinocerebellar ataxia Spinocerebellar Ataxias - diagnostic imaging |
| title | Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias |
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