Differential value of brain magnetic resonance imaging in multiple system atrophy cerebellar phenotype and spinocerebellar ataxias

Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.17329-7, Article 17329
Hauptverfasser:	Kim, Minkyeong, Ahn, Jong Hyeon, Cho, Yoonsu, Kim, Ji Sun, Youn, Jinyoung, Cho, Jin Whan
Format:	Artikel
Sprache:	eng
Schlagworte:	692/617/375/2014 692/617/375/364 Adult Aged Atrophy Cerebellum Cerebellum - diagnostic imaging Diagnosis, Differential Female Humanities and Social Sciences Humans Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged multidisciplinary Multiple System Atrophy - diagnostic imaging Neuroimaging NMR Nuclear magnetic resonance Phenotype Phenotypes Retrospective Studies Science Science (multidisciplinary) Sensitivity and Specificity Spinocerebellar ataxia Spinocerebellar Ataxias - diagnostic imaging
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Zusammenfassung:	Clinically differentiating multiple system atrophy cerebellar (MSA-C) phenotype and spinocerebellar ataxias (SCAs) is challenging especially in the early stage. We assessed diagnostic value of brain magnetic resonance imaging (MRI) in differentiating MSA-C and SCAs based at different disease stages (7 years of disease duration). Overall, 186 patients with probable MSA-C and 117 with genetically confirmed SCAs were included. Hot cross bun (HCB) signs and middle cerebellar peduncle (MCP) hyperintensities were exclusively prevalent in MSA-C compared to SCAs at
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-53980-y