Genomic and epidemiological monitoring of yellow fever virus transmission potential

The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-08, Vol.361 (6405), p.894-899
Hauptverfasser:	Faria, N R, Kraemer, M U G, Hill, S C, Goes de Jesus, J, Aguiar, R S, Iani, F C M, Xavier, J, Quick, J, du Plessis, L, Dellicour, S, Thézé, J, Carvalho, R D O, Baele, G, Wu, C-H, Silveira, P P, Arruda, M B, Pereira, M A, Pereira, G C, Lourenço, J, Obolski, U, Abade, L, Vasylyeva, T I, Giovanetti, M, Yi, D, Weiss, D J, Wint, G R W, Shearer, F M, Funk, S, Nikolay, B, Fonseca, V, Adelino, T E R, Oliveira, M A A, Silva, M V F, Sacchetto, L, Figueiredo, P O, Rezende, I M, Mello, E M, Said, R F C, Santos, D A, Ferraz, M L, Brito, M G, Santana, L F, Menezes, M T, Brindeiro, R M, Tanuri, A, Dos Santos, F C P, Cunha, M S, Nogueira, J S, Rocco, I M, da Costa, A C, Komninakis, S C V, Azevedo, V, Chieppe, A O, Araujo, E S M, Mendonça, M C L, Dos Santos, C C, Dos Santos, C D, Mares-Guia, A M, Nogueira, R M R, Sequeira, P C, Abreu, R G, Garcia, M H O, Abreu, A L, Okumoto, O, Kroon, E G, de Albuquerque, C F C, Lewandowski, K, Pullan, S T, Carroll, M, de Oliveira, T, Sabino, E C, Souza, R P, Suchard, M A, Lemey, P, Trindade, G S, Drumond, B P, Filippis, A M B, Loman, N J, Cauchemez, S, Alcantara, L C J, Pybus, O G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes Aedes - virology Age composition Age Factors Animals Aquatic insects Brazil - epidemiology Disease Outbreaks - prevention & control Disease Outbreaks - statistics & numerical data Disease transmission Epidemics Epidemiological Monitoring Epidemiology Evolution, Molecular Fever Genomes Genomics Genomics - methods Humans Life Sciences Monitoring Mosquitoes Phylogeny Polymerase Chain Reaction Primates Risk Rural Urban Differences Sex Factors Spatio-Temporal Analysis Vaccines Vector-borne diseases Viruses Yellow Fever - epidemiology Yellow Fever - prevention & control Yellow Fever - transmission Yellow Fever - virology Yellow fever virus - classification Yellow fever virus - genetics Yellow fever virus - isolation & purification
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The yellow fever virus (YFV) epidemic in Brazil is the largest in decades. The recent discovery of YFV in Brazilian species mosquitos highlights a need to monitor the risk of reestablishment of urban YFV transmission in the Americas. We use a suite of epidemiological, spatial, and genomic approaches to characterize YFV transmission. We show that the age and sex distribution of human cases is characteristic of sylvatic transmission. Analysis of YFV cases combined with genomes generated locally reveals an early phase of sylvatic YFV transmission and spatial expansion toward previously YFV-free areas, followed by a rise in viral spillover to humans in late 2016. Our results establish a framework for monitoring YFV transmission in real time that will contribute to a global strategy to eliminate future YFV epidemics.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.aat7115