Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

Antimicrobial-resistant Gram-negative colonization in infants from a neonatal intensive care unit in Thailand

Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive c...

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Veröffentlicht in:The Journal of hospital infection 2019-10, Vol.103 (2), p.151-155
Hauptverfasser: Roberts, T., Limmathurotsakul, D., Turner, P., Day, N.P.J., Vandepitte, W.P., Cooper, B.S.
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial resistance
beta-Lactamases - genetics
Carbapenem resistance
Carrier State - epidemiology
Carrier State - microbiology
Colonization
Drug Resistance, Bacterial
Extended-spectrum beta-lactamase
Female
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Humans
Infant
Infant, Newborn
Intensive Care Units, Neonatal
Longitudinal Studies
Male
Neonate
Thailand - epidemiology
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Zusammenfassung:Antimicrobial-resistant Gram-negative bacteria are a major cause of morbidity and mortality in hospitalized neonates in South and South-East Asia. This study aimed to determine the dynamics of colonization with antimicrobial-resistant Gram-negative bacteria amongst patients in a neonatal intensive care unit (NICU) in Thailand. From 97 enrolled patients, 52% were colonized by an extended-spectrum β-lactamase (ESBL) organism at some point during their stay and 64% were colonized by a carbapenem-resistant organism. Rapid acquisition of ESBL-positive and carbapenem-resistant organisms was found. Once colonized with an antibiotic-resistant organism, patients remained colonized for the remainder of their NICU stay.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2019.04.004