Pluripotent Cell Models for Gonadal Research

Sex development is a complex process involving many genes and hormones. Defects in this process lead to Differences of Sex Development (DSD), a group of heterogeneous conditions not as rare as previously thought. Part of the obstacles in proper management of these patients is due to an incomplete un...

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Veröffentlicht in:International journal of molecular sciences 2019-11, Vol.20 (21), p.5495
Hauptverfasser: Rodríguez Gutiérrez, Daniel, Biason-Lauber, Anna
Format: Artikel
Sprache:eng
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Zusammenfassung:Sex development is a complex process involving many genes and hormones. Defects in this process lead to Differences of Sex Development (DSD), a group of heterogeneous conditions not as rare as previously thought. Part of the obstacles in proper management of these patients is due to an incomplete understanding of the genetics programs and molecular pathways involved in sex development and DSD. Several challenges delay progress and the lack of a proper model system for the single patient severely hinders advances in understanding these diseases. The revolutionary techniques of cellular reprogramming and guided in vitro differentiation allow us now to exploit the versatility of induced pluripotent stem cells to create alternatives models for DSD, ideally on a patient-specific personalized basis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20215495