Mechanisms of hyperinsulinaemia in apparently healthy non-obese young adults: role of insulin secretion, clearance and action and associations with plasma amino acids

Aims/hypothesis This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia. Methods Non-obese (BMI

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Bibliographische Detailangaben
Veröffentlicht in:	Diabetologia 2019-12, Vol.62 (12), p.2310-2324
Hauptverfasser:	Hamley, Steven, Kloosterman, Danielle, Duthie, Tamara, Dalla Man, Chiara, Visentin, Roberto, Mason, Shaun A., Ang, Teddy, Selathurai, Ahrathy, Kaur, Gunveen, Morales-Scholz, Maria G., Howlett, Kirsten F., Kowalski, Greg M., Shaw, Christopher S., Bruce, Clinton R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amino acids Amino Acids - blood Beta cells Blood Glucose - metabolism Cholesterol Diabetes Fasting Fasting - blood Female Glucose Glucose tolerance Glucose Tolerance Test Human Physiology Humans Hyperinsulinism - blood Hyperinsulinism - metabolism Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology Insulin secretion Insulin Secretion - physiology Internal Medicine Lipids - blood Male Medicine Medicine & Public Health Metabolic Diseases Obesity Secretion Young Adult Young adults
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Beschreibung
Zusammenfassung:	Aims/hypothesis This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia. Methods Non-obese (BMI
ISSN:	0012-186X 1432-0428
DOI:	10.1007/s00125-019-04990-y