Evaluation of Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Cervical Intraepithelial Neoplasia Recurrence

Background: Immune system status is a factor related to cervical intraepithelial neoplasia (CIN) recurrence. neutrophil-lymphocyte ratio (NLR) is a useful factor in assessing the immune status. The aim of this study was to evaluate the prognostic value of NLR factor for CIN recurrence in patient who...

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Veröffentlicht in:	Asian Pacific Journal of Cancer Prevention 2019-08, Vol.20 (8), p.2365-2372
Hauptverfasser:	Farzaneh, Farah, Faghih, Nafiseh, Hosseini, Maryam Sadat, Arab, Maliheh, Ashrafganjoei, Tahereh, Bahman, Atyeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - analysis Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - surgery Female Follow-Up Studies Humans Leukocyte Count Lymphocytes - pathology Middle Aged Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neutrophils - pathology Prognosis Retrospective Studies Survival Rate Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery
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Zusammenfassung:	Background: Immune system status is a factor related to cervical intraepithelial neoplasia (CIN) recurrence. neutrophil-lymphocyte ratio (NLR) is a useful factor in assessing the immune status. The aim of this study was to evaluate the prognostic value of NLR factor for CIN recurrence in patient who underwent excisional procedure and its relationship with recurrence free survival (RFS). Methods: In this historical cohort study, a population of 307 patients with CIN (confirmed by excisional pathology) from 2009 to 2017 were selected. NLR and hematologic factors were measured before surgery and the follow-up records of these patient were analyzed. The recurrence rate and RFS were assessed during the follow-up phase. Results: The NLR cut-off point of 1.9 was determined using the Youden Index. NLR
ISSN:	2476-762X 1513-7368 2476-762X
DOI:	10.31557/APJCP.2019.20.8.2365