Photoredox-catalyzed stereoselective alkylation of enamides with N -hydroxyphthalimide esters via decarboxylative cross-coupling reactions

Stereoselective β-C(sp )-H alkylation of enamides with redox-active -hydroxyphthalimide esters a photoredox-catalyzed decarboxylative cross-coupling reaction is demonstrated. This methodology features operational simplicity, broad substrate scopes, and excellent stereoselectivities and functional group tolerance, affording a diverse array of geometrically defined and synthetically valuable enamides bearing primary, secondary or tertiary alkyl groups in satisfactory yields.