Allogeneic hematopoietic cell transplantation compared to chemotherapy consolidation in older acute myeloid leukemia (AML) patients 60–75 years in first complete remission (CR1): an alliance (A151509), SWOG, ECOG-ACRIN, and CIBMTR study

Allogeneic hematopoietic cell transplantation compared to chemotherapy consolidation in older acute myeloid leukemia (AML) patients 60–75 years in first complete remission (CR1): an alliance (A151509), SWOG, ECOG-ACRIN, and CIBMTR study

The preferred post-remission therapy for older patients with acute myeloid leukemia (AML) in first complete remission (CR1) remains uncertain. In this retrospective, multicenter study, we compared the outcomes for older AML patients (age 60–77 years) receiving allogeneic hematopoietic cell transplan...

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Veröffentlicht in:Leukemia 2019-11, Vol.33 (11), p.2599-2609
Hauptverfasser: Ustun, Celalettin, Le-Rademacher, Jennifer, Wang, Hai-Lin, Othus, Megan, Sun, Zhuoxin, Major, Brittny, Zhang, Mei-Jie, Storrick, Elizabeth, Lafky, Jacqueline M., Chow, Selina, Mrózek, Krzysztof, Attar, Eyal C., Nand, Such, Bloomfield, Clara D., Cripe, Larry D., Tallman, Martin S., Appelbaum, Frederick, Larson, Richard A., Marcucci, Guido, Roboz, Gail J., Uy, Geoffrey L., Stone, Richard M., Jatoi, Aminah, Shea, Thomas C., de Lima, Marcos, Foran, James M., Sandmaier, Brenda M., Litzow, Mark R., Erba, Harry P., Hurria, Arti, Weisdorf, Daniel J., Artz, Andrew S.
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Sprache:eng
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Acute myeloid leukemia
Aged
Antineoplastic Agents - therapeutic use
Cancer
Cancer Research
Chemotherapy
Clinical trials
Consolidation
Critical Care Medicine
Cytogenetics
Disease-Free Survival
Female
Hematology
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Humans
Intensive
Internal Medicine
Leukemia
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - therapy
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Myeloid leukemia
Oncology
Patients
Remission
Remission (Medicine)
Remission Induction
Retrospective Studies
Risk Factors
Stem cell transplantation
Survival
Transplantation
Transplantation, Homologous
Treatment Outcome
United States
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Zusammenfassung:The preferred post-remission therapy for older patients with acute myeloid leukemia (AML) in first complete remission (CR1) remains uncertain. In this retrospective, multicenter study, we compared the outcomes for older AML patients (age 60–77 years) receiving allogeneic hematopoietic cell transplantation (alloHCT) ( n  = 431) with those treated on prospective National Clinical Trials Network induction and nontransplantation chemotherapy (CT) consolidation trials ( n  = 211). AlloHCT patients were younger (median age: 64.2 versus 67.9 years, p  
ISSN:0887-6924
1476-5551
1476-5551
DOI:10.1038/s41375-019-0477-x