Low Levels of Low-Density Lipoprotein Cholesterol and Mortality Outcomes in Non-Statin Users

Low Levels of Low-Density Lipoprotein Cholesterol and Mortality Outcomes in Non-Statin Users

We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To...

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Veröffentlicht in:Journal of clinical medicine 2019-10, Vol.8 (10), p.1571
Hauptverfasser: Sung, Ki-Chul, Huh, Ji Hye, Ryu, Seungho, Lee, Jong-Young, Scorletti, Eleonora, Byrne, Christopher D, Kim, Jang Young, Hyun, Dae Sung, Ko, Sang-Baek
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Sprache:eng
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Zusammenfassung:We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these associations, we analyzed data from another cohort (Korean genome and epidemiology study, KoGES, 182,943 subjects). All subjects treated with any lipid-lowering therapy and who died during the first 3 years of follow up were excluded. Five groups were defined according to baseline LDL-C concentration (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm8101571