Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma

Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma

The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010...

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Veröffentlicht in:Bioscience reports 2019-10, Vol.39 (10)
Hauptverfasser: Xia, Bing, Wang, Xi, Yang, Ruifang, Li, Mengzhen, Yang, Kunpeng, Ren, Li, Li, Suxia, Wang, Shuye, Zhang, Yizhuo
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Cancer
Evolutionary Biology
Gene Expression & Regulation
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container_issue 10
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container_title Bioscience reports
container_volume 39
creator Xia, Bing
Wang, Xi
Yang, Ruifang
Li, Mengzhen
Yang, Kunpeng
Ren, Li
Li, Suxia
Wang, Shuye
Zhang, Yizhuo
description The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P
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Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P&lt;0.05). Correlation analysis showed that the expression of EBV-DNA was positively correlated with the serum free light chain ratio (sFLCR) and disease PD/relapse (P&lt;0.05). Especially, in EBV-DNA high-expression MM patients, EBV-DNA concentration forpatients with sFLCR≥100 was higher than that of patients with sFLCR&lt;100. EBV-DNA concentration was higher in patients with disease PD/relapse than those without disease PD/relapse. In univariate analysis, the progress free survival(PFS)was inferior in MM patients with high expression of EBV-DNA, high LDH, and high-risk according to mSMART and IMWG, stage III according to R-ISS staging, extramedullary lesions, and genetic changes (P&lt;0.05). However, in multivariate analysis, LDH, poor karyotype, R-ISS staging and mSMART were independent prognostic factors for PFS. Taken together, our studies suggest that an association exists between EBV infection and clinical characteristics of MM patients, and EBV infection appears to have a slight impact on the prognosis of MM. However, the results require further validation in other independent prospective MM cohorts.</description><identifier>ISSN: 0144-8463</identifier><identifier>EISSN: 1573-4935</identifier><identifier>DOI: 10.1042/BSR20190284</identifier><identifier>PMID: 30967494</identifier><language>eng</language><publisher>England: Portland Press Ltd</publisher><subject>Cancer ; Evolutionary Biology ; Gene Expression &amp; Regulation</subject><ispartof>Bioscience reports, 2019-10, Vol.39 (10)</ispartof><rights>2019 The Author(s).</rights><rights>2019 The Author(s). 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-b7a4c465d3bc2e00a46405be1c9a9a89058b011a3c7da96e3e9ed9523fba82e23</citedby><cites>FETCH-LOGICAL-c381t-b7a4c465d3bc2e00a46405be1c9a9a89058b011a3c7da96e3e9ed9523fba82e23</cites><orcidid>0000-0002-1529-6671</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822490/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822490/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30967494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Bing</creatorcontrib><creatorcontrib>Wang, Xi</creatorcontrib><creatorcontrib>Yang, Ruifang</creatorcontrib><creatorcontrib>Li, Mengzhen</creatorcontrib><creatorcontrib>Yang, Kunpeng</creatorcontrib><creatorcontrib>Ren, Li</creatorcontrib><creatorcontrib>Li, Suxia</creatorcontrib><creatorcontrib>Wang, Shuye</creatorcontrib><creatorcontrib>Zhang, Yizhuo</creatorcontrib><title>Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma</title><title>Bioscience reports</title><addtitle>Biosci Rep</addtitle><description>The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P&lt;0.05). Correlation analysis showed that the expression of EBV-DNA was positively correlated with the serum free light chain ratio (sFLCR) and disease PD/relapse (P&lt;0.05). Especially, in EBV-DNA high-expression MM patients, EBV-DNA concentration forpatients with sFLCR≥100 was higher than that of patients with sFLCR&lt;100. EBV-DNA concentration was higher in patients with disease PD/relapse than those without disease PD/relapse. In univariate analysis, the progress free survival(PFS)was inferior in MM patients with high expression of EBV-DNA, high LDH, and high-risk according to mSMART and IMWG, stage III according to R-ISS staging, extramedullary lesions, and genetic changes (P&lt;0.05). However, in multivariate analysis, LDH, poor karyotype, R-ISS staging and mSMART were independent prognostic factors for PFS. Taken together, our studies suggest that an association exists between EBV infection and clinical characteristics of MM patients, and EBV infection appears to have a slight impact on the prognosis of MM. 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Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P&lt;0.05). Correlation analysis showed that the expression of EBV-DNA was positively correlated with the serum free light chain ratio (sFLCR) and disease PD/relapse (P&lt;0.05). Especially, in EBV-DNA high-expression MM patients, EBV-DNA concentration forpatients with sFLCR≥100 was higher than that of patients with sFLCR&lt;100. EBV-DNA concentration was higher in patients with disease PD/relapse than those without disease PD/relapse. In univariate analysis, the progress free survival(PFS)was inferior in MM patients with high expression of EBV-DNA, high LDH, and high-risk according to mSMART and IMWG, stage III according to R-ISS staging, extramedullary lesions, and genetic changes (P&lt;0.05). However, in multivariate analysis, LDH, poor karyotype, R-ISS staging and mSMART were independent prognostic factors for PFS. Taken together, our studies suggest that an association exists between EBV infection and clinical characteristics of MM patients, and EBV infection appears to have a slight impact on the prognosis of MM. However, the results require further validation in other independent prospective MM cohorts.</abstract><cop>England</cop><pub>Portland Press Ltd</pub><pmid>30967494</pmid><doi>10.1042/BSR20190284</doi><orcidid>https://orcid.org/0000-0002-1529-6671</orcidid><oa>free_for_read</oa></addata></record>
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Evolutionary Biology
Gene Expression & Regulation
title Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma
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