Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma

Epstein-Barr virus infection is associated with clinical characteristics and poor prognosis of multiple myeloma

The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010...

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Veröffentlicht in:Bioscience reports 2019-10, Vol.39 (10)
Hauptverfasser: Xia, Bing, Wang, Xi, Yang, Ruifang, Li, Mengzhen, Yang, Kunpeng, Ren, Li, Li, Suxia, Wang, Shuye, Zhang, Yizhuo
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Evolutionary Biology
Gene Expression & Regulation
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Zusammenfassung:The aim of this study was to evaluate the relationship of Epstein-Barr virus (EBV) infection and multiple myeloma (MM) and its impact on clinical characteristics and prognosis. Fresh peripheral blood mononuclear cells (PBMCs) from 139 MM patients who had been diagnosed and treated from January 2010 to May 2018 and 50 PBMCs samples from healthy donors were obtained. Polymerase chain reaction (PCR) was carried out for detection of EBV-DNA. The results indicated a significantly higher EBV-DNA concentration among 139 MM patients compared with healthy controls (P
ISSN:0144-8463
1573-4935
DOI:10.1042/BSR20190284