Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

Trimethylamine-N-Oxide (TMAO) Predicts Cardiovascular Mortality in Peripheral Artery Disease

Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by...

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Veröffentlicht in:Scientific reports 2019-10, Vol.9 (1), p.15580-8, Article 15580
Hauptverfasser: Roncal, Carmen, Martínez-Aguilar, Esther, Orbe, Josune, Ravassa, Susana, Fernandez-Montero, Alejandro, Saenz-Pipaon, Goren, Ugarte, Ana, Estella-Hermoso de Mendoza, Ander, Rodriguez, Jose A., Fernández-Alonso, Sebastián, Fernández-Alonso, Leopoldo, Oyarzabal, Julen, Paramo, Jose A.
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Sprache:eng
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Aged
Arteriosclerosis
Cardiovascular diseases
Digestive system
Dimethylaniline monooxygenase (N-oxide-forming)
Female
Gastrointestinal tract
Health risks
Humanities and Social Sciences
Humans
Intestine
Ischemia
Male
Mass spectrometry
Mass spectroscopy
Metabolites
Methylamines - metabolism
Mortality
multidisciplinary
Oxidation
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - metabolism
Peripheral Arterial Disease - mortality
Plasma levels
Prognosis
Renal function
Risk Assessment
Science
Science (multidisciplinary)
Trimethylamine
Trimethylamine-N-oxide
Vascular diseases
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Zusammenfassung:Peripheral artery disease (PAD) is a major cause of acute and chronic illness, with extremely poor prognosis that remains underdiagnosed and undertreated. Trimethylamine-N-Oxide (TMAO), a gut derived metabolite, has been associated with atherosclerotic burden. We determined plasma levels of TMAO by mass spectrometry and evaluated their association with PAD severity and prognosis. 262 symptomatic PAD patients (mean age 70 years, 87% men) categorized in intermittent claudication (IC, n = 147) and critical limb ischemia (CLI, n = 115) were followed-up for a mean average of 4 years (min 1-max 102 months). TMAO levels were increased in CLI compared to IC (P  2.26 µmol/L exhibited higher risk of cardiovascular death (sub-hazard ratios ≥2, P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-52082-z