Neurotuberculosis: Control of Steroid-Refractory Paradoxical Inflammatory Reaction With Ruxolitinib

Neurotuberculosis: Control of Steroid-Refractory Paradoxical Inflammatory Reaction With Ruxolitinib

Paradoxical inflammatory reactions associated with treatment of neurotuberculosis can lead to severe morbidity and mortality and may not be controlled by steroids alone. We report the use of the Janus kinase inhibitor ruxolitinib to treat a steroid-refractory neurotuberculosis paradoxical reaction.

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Bibliographische Detailangaben
Veröffentlicht in:Open Forum Infectious Diseases 2019-10, Vol.6 (10), p.ofz422-ofz422
Hauptverfasser: Xie, Yingda L, Ita-Nagy, Fanny, Chen, Ray Y, Manion, Maura M, Sereti, Irini, Pei, Luxin, Holland, Steven M
Format: Artikel
Sprache:eng
Schlagworte:
Adverse and side effects
Brief Report
Care and treatment
Drugs
Editor's Choice
Tuberculosis
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Beschreibung
Zusammenfassung:Paradoxical inflammatory reactions associated with treatment of neurotuberculosis can lead to severe morbidity and mortality and may not be controlled by steroids alone. We report the use of the Janus kinase inhibitor ruxolitinib to treat a steroid-refractory neurotuberculosis paradoxical reaction.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofz422