Langerhans Cells Spy on Keratinocytes

Langerhans Cells Spy on Keratinocytes

Tunneling nanotubes (TNTs) have been described as a novel mechanism for intercellular communication. However, the ability of epidermal cells to utilize TNTs remains a mystery. In this issue, Su and Igyártó (2019) showed that Langerhans cells (LCs) obtain mRNA from keratinocytes (KC) in vivo presumab...

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Veröffentlicht in:Journal of investigative dermatology 2019-11, Vol.139 (11), p.2260-2262
Hauptverfasser: De La Cruz Diaz, Jacinto S., Kaplan, Daniel H.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Communication
Keratinocytes
Langerhans Cells
Nanotubes
RNA, Messenger
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Zusammenfassung:Tunneling nanotubes (TNTs) have been described as a novel mechanism for intercellular communication. However, the ability of epidermal cells to utilize TNTs remains a mystery. In this issue, Su and Igyártó (2019) showed that Langerhans cells (LCs) obtain mRNA from keratinocytes (KC) in vivo presumably via TNTs. The demonstration of exchange of genetic material from KC to LC in vivo is an an unexpected method of antigen acquisition by LC and also an important consideration when analyzing transcriptomic data.
ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2019.06.120