IL10 haplotypes are associated with diabetic nephropathy susceptibility in patients from western Mexico

Introduction Diabetic Nephropathy (DN) is the main cause of chronic kidney disease (CKD) in diabetic patients. An IL‐10 imbalance could be related to renal hypertrophy and trigger to nephropathy. Three promoter polymorphisms (‐1082G>A, ‐819C>T, and ‐592C>A) at IL10 gene have been associated with changes in the IL‐10 expression and DN susceptibility. Therefore, the aim of this study was to analyze this association in Mexican patients with DN. Methods We conducted a case‐control study on 128 patients with DN and 150 control subjects (CS) from western Mexico. All patients were tested for IL10 polymorphisms by PCR‐RFLP. Allele frequencies, genotypes, and haplotypes were compared between groups. The significant haplotypes were correlated with patient clinical features. Results IL10 gene ATC haplotype (‐1082A/‐819T/‐592C) was found significantly more frequent in DN patients than in CS (P