Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3
Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 ( ATF3 −/−...
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Veröffentlicht in: | Communications biology 2019-10, Vol.2 (1), p.389-389, Article 389 |
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Sprache: | eng |
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Zusammenfassung: | Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning of white adipose tissue has been suggested as a potential strategy, but a drug still needs to be identified. Here, genetic deletion of activating transcription factor 3 (
ATF3
−/−
) in mice under a high-fat diet (HFD) resulted in obesity and insulin resistance, which was abrogated by virus-mediated ATF3 restoration. ST32da, a synthetic ATF3 inducer isolated from
Salvia miltiorrhiza
, promoted ATF3 expression to downregulate adipokine genes and induce adipocyte browning by suppressing the carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased white adipose tissue browning and reduced lipogenesis in HFD-induced obese mice. The anti-obesity efficacy of oral ST32da administration was similar to that of the clinical drug orlistat. Our study identified the ATF3 inducer ST32da as a promising therapeutic drug for treating diet-induced obesity and related metabolic disorders.
Ching-Feng Cheng et al. find that expression of the transcription factor ATF3 in mice provides protection from obesity and insulin resistance under a high-fat diet. They show that expression of ATF3 can be induced by ST32da, a compound derived from the Chinese sage plant,
Salvia miltiorrhiza
. |
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ISSN: | 2399-3642 2399-3642 |
DOI: | 10.1038/s42003-019-0624-y |