Serum 25-Hydroxyvitamin D Level and Extent and Complexity of Coronary Artery Disease

Background There are limited number of studies about relationship between serum vitamin D level and presence and severity of coronary artery disease (CAD). We assessed the relationship between the extent and complexity of CAD assessed by SYNTAX score and 25‐hydroxyvitamin D level in patients with stable CAD. Methods In the study, 209 consecutive patients with stable CAD (age: 63.1 ± 10.0 years) and 102 healthy control subjects (age 61.3 ± 13.7 years) were included. Serum 25‐hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay and other biochemical markers were measured in all subjects. All subjects underwent coronary angiography and SS was calculated. Results The mean serum 25‐hydroxyvitamin D level of CAD group was lower than the control group (P < 0,001). Multivariate regression analysis showed that serum 25‐hydroxyvitamin D level was independently associated with SYNTAX score (β = −0.396, P < 0.001), hypertension (β = −0.183, P = 0.003), high sensitive C‐reactive protein (β = −0.141, P = 0.014), and body mass index (β = −0.135, P = 0.023) in patient group. Conclusion 25‐Hydroxyvitamin D level was associated with extent and complexity of CAD. 25‐Hydroxyvitamin D may play a role in pathogenesis and severity of coronary atherosclerosis.