Baseline Characteristics of Randomized Participants in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)

GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin in people with type 2 diabetes (T2DM). We report baseline characteristics and co...

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Veröffentlicht in:	Diabetes care 2019-11, Vol.42 (11), p.2098-2107
Hauptverfasser:	Wexler, Deborah J, Krause-Steinrauf, Heidi, Crandall, Jill P, Florez, Hermes J, Hox, Sophia H, Kuhn, Alexander, Sood, Ajay, Underkofler, Chantal, Aroda, Vanita R
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Antidiabetics Blood glucose Blood Glucose - drug effects Cardiovascular diseases Cohort Studies Comparative Effectiveness Research Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Drug Therapy, Combination Effectiveness studies Emerging Therapies: Drugs and Regimens Female Glycated Hemoglobin - drug effects Heart Humans Hyperlipidemia Hypertension Hypoglycemic Agents - administration & dosage Insulin Insulin Glargine - administration & dosage Liraglutide - administration & dosage Male Metformin Metformin - administration & dosage Middle Aged Minority & ethnic groups Myocardial infarction Nutrition Nutrition Surveys Randomization Reduction Research design Sitagliptin Phosphate - administration & dosage Sulfonylurea Compounds - administration & dosage Treatment Outcome
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Zusammenfassung:	GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) is a 36-center unmasked, parallel treatment group, randomized controlled trial evaluating four diabetes medications added to metformin in people with type 2 diabetes (T2DM). We report baseline characteristics and compare GRADE participants to a National Health and Nutrition Examination Survey (NHANES) cohort. Participants were age ≥30 years at the time of diagnosis, with duration of T2DM
ISSN:	0149-5992 1935-5548 1935-5548
DOI:	10.2337/dc19-0901