Circulating Tumor Cell Clusters in Patients with Metastatic Breast Cancer: a SWOG S0500 Translational Medicine Study

Metastasis requires malignant cell circulation from the primary to a distant tissue. Elevated levels of circulating tumor cells (CTC) portend a poor prognosis in breast and other cancers. Recent studies have suggested that CTC clusters may be a factor in the metastatic process. We conducted a prospe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2019-10, Vol.25 (20), p.6089-6097
Hauptverfasser:	Paoletti, Costanza, Miao, Jieling, Dolce, Emily M, Darga, Elizabeth P, Repollet, Madeline I, Doyle, Gerald V, Gralow, Julie R, Hortobagyi, Gabriel N, Smerage, Jeffrey B, Barlow, William E, Hayes, Daniel F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Metastasis requires malignant cell circulation from the primary to a distant tissue. Elevated levels of circulating tumor cells (CTC) portend a poor prognosis in breast and other cancers. Recent studies have suggested that CTC clusters may be a factor in the metastatic process. We conducted a prospective retrospective study of the SWOG0500 clinical trial to test whether CTC clusters are associated with poorer prognosis. CTC CellSearch galleries from SWOG0500 trial were reread using prespecified criteria for CTC clusters, doublets, and enumeration. Survival analysis methods include Kaplan-Meier plots and log-rank tests. Patients were classified into three prognostic subgroups based on baseline CTC/7.5 mL whole blood (WB): Arm A:
ISSN:	1078-0432 1557-3265
DOI:	10.1158/1078-0432.CCR-19-0208