Biomarkers of oral inflammation in perinatally HIV‐infected and perinatally HIV‐exposed, uninfected youth

Aim To examine oral biomarkers that have been associated with periodontal disease progression in HIV‐infected adults in perinatally HIV‐infected and HIV‐exposed but uninfected youth. Material and Methods This was a cross‐sectional, multicentre substudy of youth participating in the Oral Health Pedia...

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Veröffentlicht in:	Journal of clinical periodontology 2019-11, Vol.46 (11), p.1072-1082
Hauptverfasser:	Moscicki, Anna‐Barbara, Yao, Tzy‐Jyun, Russell, Jonathan S., Farhat, Sepideh, Scott, Mark, Magpantay, Larry, Halec, Gordana, Shiboski, Caroline H., Ryder, Mark I., Yang, Ester, Shearer, William, Paul, Mary, Cooper, Norma, Harris, Lynette, Kemp‐Posterman, Karen, Wun, Selene, Purswani, Murli, Baig, Mahboobullah, Cintron, Anna, Zeni, Jennifer, Puga, Ana, Navarro, Sandra, Patton, Doyle, Leon, Deyana, Ng, Man Wai, Burchett, Sandra, Karthas, Nancy, Kammerer, Betsy, Jurado, Ray, Kuttab, Johnny, Vorachek, Ashlee, Yogev, Ram, Sanders, Margaret Ann, Malee, Kathleen, Hunter, Scott, Badner, Victor, Garreett, Ronald, Wiznia, Andrew, Burey, Marlene, Nozyce, Molly, Chialastri, Susan, Chen, Janet, Ivey, Latreca, Bulkley, Maria Garcia, Grant, Mitzie, Gonzalez, Ramon, Acevedo‐Flores, Midnela, Rios, Heida, Olivera, Vivian, Townsend, Janice, Silio, Margarita, Jones, Medea, Sirois, Patricia, Gandhi, Roopa, McFarland, Elizabeth, Barr, Emily, McEvoy, Robin, Markowitz, Kenneth, Dieudonne, Arry, Bettica, Linda, Adubato, Susan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adolescent Adult AIDS Biomarkers CD14 antigen Child Cohort Studies Cross-Sectional Studies cytokines Dentistry Female Gingival Crevicular Fluid Gingival index HIV HIV Infections Human immunodeficiency virus Humans Immune response Inflammation Macrophage inflammatory protein Metalloproteinase oral health perinatal HIV‐infected youth Periodontal diseases periodontal inflammation Pregnancy Tumor necrosis factor Tumors
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Beschreibung
Zusammenfassung:	Aim To examine oral biomarkers that have been associated with periodontal disease progression in HIV‐infected adults in perinatally HIV‐infected and HIV‐exposed but uninfected youth. Material and Methods This was a cross‐sectional, multicentre substudy of youth participating in the Oral Health Pediatric HIV/AIDS Cohort study. Gingival crevicular fluid repository samples from participants with and without periodontal disease (using Gingival Index [GI] and Bleeding on Probing [BOP] parameters on dental examination) were tested for concentration levels of inflammatory biomarkers. Associations were assessed using Wilcoxon test and Spearman correlation. Results For perinatal HIV youth (n = 129), the markers consistently elevated (p
ISSN:	0303-6979 1600-051X
DOI:	10.1111/jcpe.13179